AKAP12

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Full Name

A-Kinase Anchoring Protein 12

Function

Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Cellular response to interleukin-1 Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
G protein-coupled receptor signaling pathway Source: ProtInc
Hepatic stellate cell activation Source: Ensembl
Modulation of chemical synaptic transmission Source: Ensembl
Negative regulation of vascular permeability Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of hepatic stellate cell migration Source: Ensembl
Positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
Positive regulation of oligodendrocyte apoptotic process Source: Ensembl
Positive regulation of protein kinase A signaling Source: InterPro
Regulation of protein kinase A signaling Source: UniProtKB
Regulation of protein kinase C signaling Source: InterPro
Response to electrical stimulus Source: Ensembl
Response to lipopolysaccharide Source: Ensembl

Cellular Location

Cytoskeleton; Cell cortex; Membrane. May be part of the cortical cytoskeleton.