Human AKAP12 ELISA Kit (V2LY-0626-LY4055)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.0076 ng/mL
Detection Range
0.015-3.8 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
191.5 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
A-Kinase Anchoring Protein 12
Function
Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Cellular response to interleukin-1 Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
G protein-coupled receptor signaling pathway Source: ProtInc
Hepatic stellate cell activation Source: Ensembl
Modulation of chemical synaptic transmission Source: Ensembl
Negative regulation of vascular permeability Source: Ensembl
Positive regulation of ERK1 and ERK2 cascade Source: Ensembl
Positive regulation of hepatic stellate cell migration Source: Ensembl
Positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
Positive regulation of oligodendrocyte apoptotic process Source: Ensembl
Positive regulation of protein kinase A signaling Source: InterPro
Regulation of protein kinase A signaling Source: UniProtKB
Regulation of protein kinase C signaling Source: InterPro
Response to electrical stimulus Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Cellular Location
Cytoskeleton; Cell cortex; Membrane. May be part of the cortical cytoskeleton.

Bai, Y., Yuan, R., Luo, Y., Kang, Z., Zhu, H., Qu, L., ... & Song, X. (2021). Exploration of Genetic Variants within the Goat A-Kinase Anchoring Protein 12 (AKAP12) Gene and Their Effects on Growth Traits. Animals, 11(7), 2090.

Mamoor, S. (2021). Differential expression of A-kinase anchoring protein 12 in cancers of the breast.

Fonseca-Camarillo, G., Furuzawa-Carballeda, J., Priego-Ranero, Á. A., Zúñiga, R. B., Martínez-Benítez, B., & Yamamoto-Furusho, J. K. (2021). AKAP12/Gravin is over-expressed in patients with ulcerative colitis. Immunologic Research, 1-7.

Çiçek, H., Saygılı, Ö., Sever, Ö. N., Kaya, V., Ulusal, H., & Yıldırım, M. (2019). The diagnostic role of A-kinase anchoring protein 12, Bcl-2 and high mobility group box Protein-1 levels in breast cancer. Journal of Oncological Sciences, 5(3), 90-95.

Ibarrola Ulzurrun, J. F., Sádaba Sagredo, R., Martínez Martínez, E., García Peña, A., & Gaínza Calleja, A. (2018). Aldosterone impairs mitochondrial function in human cardiac fibroblasts via A-kinase anchor protein 12. Scientific Reports, 2018, 8, 6801.

Lee, H. S., Choi, J., Son, T., Lee, E. J., Kim, J. G., Ryu, S. H., ... & Kim, K. W. (2018). A‑kinase anchoring protein 12 is downregulated in human hepatocellular carcinoma and its deficiency in mice aggravates thioacetamide‑induced liver injury. Oncology letters, 16(5), 5907-5915.

Ibarrola, J., Sadaba, R., Martinez-Martinez, E., Garcia-Peña, A., Arrieta, V., Alvarez, V., ... & Lopez-Andres, N. (2018). Aldosterone impairs mitochondrial function in human cardiac fibroblasts via A-kinase anchor protein 12. Scientific reports, 8(1), 1-11.

Selvaraju, V., Suresh, S. C., Thirunavukkarasu, M., Mannu, J., Foye, J. L., Mathur, P. P., ... & Maulik, N. (2017). Regulation of A-kinase-anchoring protein 12 by heat shock protein A12B to prevent ventricular dysfunction following acute myocardial infarction in diabetic rats. Journal of cardiovascular translational research, 10(2), 209-220.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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