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ALAS1

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

Full Name

5'-Aminolevulinate Synthase 1

Biological Process

Erythrocyte development Source: GO_Central
Heme biosynthetic process Source: GO_Central
Hemoglobin biosynthetic process Source: GO_Central
Mitochondrion organization Source: Reactome
Protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Regulation of metabolic process Source: Reactome
Response to hypoxia Source: GO_Central

Cellular Location

Mitochondrion matrix

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Anti-ALAS1 antibodies

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Rabbit Anti-ALAS1 Recombinant Antibody (V2-634206) (CBMAB-AP250LY)

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Target: ALAS1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: V2-634206

Application*: WB

Mouse Anti-ALAS1 Recombinant Antibody (V2-634205) (CBMAB-AP249LY)

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Target: ALAS1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: V2-634205

Application*: IC, IF, WB, IP, E

Mouse Anti-ALAS1 Recombinant Antibody (V2-623902) (CBMAB-Ab011-LY)

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Target: ALAS1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: V2-623902

Application*: IC, IF, WB, IP, E, P

Mouse Anti-ALAS1 Recombinant Antibody (V2-611118) (CBMAB-A0271-LY)

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Target: ALAS1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: V2-611118

Application*: WB, E

Mouse Anti-ALAS1 Recombinant Antibody (V2-180596) (CBMAB-A2132-YC)

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Target: ALAS1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: V2-180596

Application*: IC, IF, WB, IP, E

Mouse Anti-ALAS1 Recombinant Antibody (V2-180595) (CBMAB-A2131-YC)

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Target: ALAS1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: V2-180595

Application*: E, WB

Mouse Anti-ALAS1 Recombinant Antibody (V2-180594) (CBMAB-A2130-YC)

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Target: ALAS1

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: V2-180594

Application*: WB

Rabbit Anti-ALAS1 Recombinant Antibody (
2A9) (V2LY-0725-LY1141)

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Target: ALAS1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 2A9

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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