ALAS1

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
Full Name
5'-Aminolevulinate Synthase 1
Biological Process
Erythrocyte development Source: GO_Central
Heme biosynthetic process Source: GO_Central
Hemoglobin biosynthetic process Source: GO_Central
Mitochondrion organization Source: Reactome
Protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Regulation of metabolic process Source: Reactome
Response to hypoxia Source: GO_Central
Cellular Location
Mitochondrion matrix
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Anti-ALAS1 antibodies

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Rabbit Anti-ALAS1 Recombinant Antibody (V2-634206) (CBMAB-AP250LY)

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Target: ALAS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-634206
Application*: WB
Datasheet SDS

Mouse Anti-ALAS1 Recombinant Antibody (V2-634205) (CBMAB-AP249LY)

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Target: ALAS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-634205
Application*: IC, IF, WB, IP, E
Datasheet SDS

Mouse Anti-ALAS1 Recombinant Antibody (V2-623902) (CBMAB-Ab011-LY)

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Target: ALAS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: V2-623902
Application*: IC, IF, WB, IP, E, P
Datasheet SDS

Mouse Anti-ALAS1 Recombinant Antibody (V2-611118) (CBMAB-A0271-LY)

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Target: ALAS1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-611118
Application*: WB, E
Datasheet SDS

Mouse Anti-ALAS1 Recombinant Antibody (V2-180596) (CBMAB-A2132-YC)

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Target: ALAS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: V2-180596
Application*: IC, IF, WB, IP, E
Datasheet SDS

Mouse Anti-ALAS1 Recombinant Antibody (V2-180595) (CBMAB-A2131-YC)

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Target: ALAS1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: V2-180595
Application*: E, WB
Datasheet SDS

Mouse Anti-ALAS1 Recombinant Antibody (V2-180594) (CBMAB-A2130-YC)

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Target: ALAS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: V2-180594
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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