ASAP1

This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Full Name
ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 1
Function
Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types (By similarity).
Plays a role in ciliogenesis.
Biological Process
Cilium assembly Source: UniProtKB
Negative regulation of dendritic spine development Source: Ensembl
Positive regulation of membrane tubulation Source: GO_Central
Positive regulation of podosome assembly Source: GO_Central
Cellular Location
Cytoplasm; Membrane. Predominantly cytoplasmic. Partially membrane-associated.
PTM
Phosphorylated on tyrosine residues by SRC.
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Anti-ASAP1 antibodies

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Mouse Anti-ASAP1 Recombinant Antibody (E12) (CBMAB-XB0059-YC)

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Target: ASAP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: E12
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ASAP1 Recombinant Antibody (4E8) (CBMAB-C6891-LY)

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Target: ASAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 4E8
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ASAP1 Recombinant Antibody (CBYC-A806) (CBMAB-A3710-YC)

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Target: ASAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBYC-A806
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-ASAP1 Recombinant Antibody (2G7) (CBMAB-A3709-YC)

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Target: ASAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: 2G7
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ASAP1 Recombinant Antibody (1B5) (CBMAB-A3708-YC)

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Target: ASAP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B5
Application*: E, WB
Datasheet SDS

Human ASAP1 ELISA Kit (V2LY-0626-LY5932)

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Target: ASAP1
Sensitivity: 0.0099 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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