ASCL2

This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. [provided by RefSeq, Jul 2008]

Full Name

Achaete-Scute Family BHLH Transcription Factor 2

Function

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Biological Process

Negative regulation of Schwann cell proliferation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Neuron differentiation Source: GO_Central
Placenta development Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to hypoxia Source: UniProtKB
Sensory organ development Source: GO_Central
Somatic stem cell population maintenance Source: Ensembl
Spongiotrophoblast differentiation Source: Ensembl
Spongiotrophoblast layer development Source: UniProtKB

Cellular Location

Nucleus