Mouse Anti-ASCL2 Recombinant Antibody (10F629) (CBMAB-A3748-YC)

Name: Mouse Anti-ASCL2 Recombinant Antibody (10F629)
SKU: CBMAB-A3748-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8F1

Application

IHC, WB

Immunogen

His-tagged recombinant protein corresponding to mouse Achaete Scute homolog 2.

Specificity

Human, Mouse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1 M Tris-Glycine, pH 7.4

Preservative

0.05% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

C-terminus

More Infomation

Target

Full Name

Achaete-Scute Family BHLH Transcription Factor 2

Introduction

ASCL2 belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determinati

Entrez Gene ID

430

UniProt ID

Q99929

Alternative Names

Achaete-Scute Family BHLH Transcription Factor 2; Class A Basic Helix-Loop-Helix Protein 45; BHLHa45; MASH2; ASH-2; HASH2; Achaete-Scute Complex (Drosophila) Homolog-Like 2; Achaete-Scute Complex Homolog 2 (Drosophila);

Function

AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.

Biological Process

Negative regulation of Schwann cell proliferation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Neuron differentiation Source: GO_Central
Placenta development Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to hypoxia Source: UniProtKB
Sensory organ development Source: GO_Central
Somatic stem cell population maintenance Source: Ensembl
Spongiotrophoblast differentiation Source: Ensembl
Spongiotrophoblast layer development Source: UniProtKB

Cellular Location

Nucleus

Varberg, K. M., Iqbal, K., Muto, M., Simon, M. E., Scott, R. L., Kozai, K., ... & Soares, M. J. (2021). ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development. Proceedings of the National Academy of Sciences, 118(10).

Sun, L., Zhao, X., Liu, X., Zhong, B., Tang, H., Jin, W., ... & Dong, C. (2021). Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription. Cell Reports, 35(9), 109188.

Liu, Z., Wang, X., Jiang, K., Ji, X., Zhang, Y. A., & Chen, Z. (2019). TNFα-induced Up-regulation of Ascl2 affects the differentiation and proliferation of neural stem cells. Aging and disease, 10(6), 1207.

Liang, C., Li, A., Raza, S. H. A., Khan, R., Wang, X., Wang, S., ... & Zan, L. (2019). The molecular characteristics of the FAM13A gene and the role of transcription factors ACSL1 and ASCL2 in its core promoter region. Genes, 10(12), 981.

Bogutz, A. B., Oh-McGinnis, R., Jacob, K. J., Ho-Lau, R., Gu, T., Gertsenstein, M., ... & Lefebvre, L. (2018). Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage. PLoS genetics, 14(8), e1007587.

Wang, J., Cai, H., Xia, Y., Wang, S., Xing, L., Chen, C., ... & Chen, T. (2018). Bufalin inhibits gastric cancer invasion and metastasis by down-regulating Wnt/ASCL2 expression. Oncotarget, 9(34), 23320.

Peters, S., Bamidele, O., De Donato, M., Omitogun, O., & Imumorin, I. (2017). Molecular cloning, sequence analysis and tissue expression of bovine imprinted ASCL2 gene. South African Journal of Animal Science, 47(6), 813-821.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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