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Mouse Anti-ASCL2 Recombinant Antibody (7E2) (CBMAB-A3747-YC)

Provided herein is a Mouse monoclonal antibody against Human Achaete-Scute Family BHLH Transcription Factor 2. The antibody can be used for immunoassay techniques, such as ICC, IP, WB.
See all ASCL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7E2
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF

Basic Information

Immunogen
His-tagged recombinant protein corresponding to human Achaete Scute homolog 2 near the C-terminus.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1 M Tris-Glycine, pH 7.4
Preservative
0.05% sodium azide
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
Achaete-Scute Family BHLH Transcription Factor 2
Introduction
ASCL2 belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determinati
Entrez Gene ID
430
UniProt ID
Q99929
Alternative Names
Achaete-Scute Family BHLH Transcription Factor 2; Class A Basic Helix-Loop-Helix Protein 45; BHLHa45; MASH2; ASH-2; HASH2; Achaete-Scute Complex (Drosophila) Homolog-Like 2; Achaete-Scute Complex Homolog 2 (Drosophila);
Function
AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system.
Biological Process
Negative regulation of Schwann cell proliferation Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Neuron differentiation Source: GO_Central
Placenta development Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of neurogenesis Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to hypoxia Source: UniProtKB
Sensory organ development Source: GO_Central
Somatic stem cell population maintenance Source: Ensembl
Spongiotrophoblast differentiation Source: Ensembl
Spongiotrophoblast layer development Source: UniProtKB
Cellular Location
Nucleus

Varberg, K. M., Iqbal, K., Muto, M., Simon, M. E., Scott, R. L., Kozai, K., ... & Soares, M. J. (2021). ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development. Proceedings of the National Academy of Sciences, 118(10).

Sun, L., Zhao, X., Liu, X., Zhong, B., Tang, H., Jin, W., ... & Dong, C. (2021). Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription. Cell Reports, 35(9), 109188.

Liu, Z., Wang, X., Jiang, K., Ji, X., Zhang, Y. A., & Chen, Z. (2019). TNFα-induced Up-regulation of Ascl2 affects the differentiation and proliferation of neural stem cells. Aging and disease, 10(6), 1207.

Liang, C., Li, A., Raza, S. H. A., Khan, R., Wang, X., Wang, S., ... & Zan, L. (2019). The molecular characteristics of the FAM13A gene and the role of transcription factors ACSL1 and ASCL2 in its core promoter region. Genes, 10(12), 981.

Bogutz, A. B., Oh-McGinnis, R., Jacob, K. J., Ho-Lau, R., Gu, T., Gertsenstein, M., ... & Lefebvre, L. (2018). Transcription factor ASCL2 is required for development of the glycogen trophoblast cell lineage. PLoS genetics, 14(8), e1007587.

Wang, J., Cai, H., Xia, Y., Wang, S., Xing, L., Chen, C., ... & Chen, T. (2018). Bufalin inhibits gastric cancer invasion and metastasis by down-regulating Wnt/ASCL2 expression. Oncotarget, 9(34), 23320.

Peters, S., Bamidele, O., De Donato, M., Omitogun, O., & Imumorin, I. (2017). Molecular cloning, sequence analysis and tissue expression of bovine imprinted ASCL2 gene. South African Journal of Animal Science, 47(6), 813-821.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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