ATP2B1

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

ATPase, Ca++ transporting, plasma membrane 1

Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts (By similarity).
Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells (PubMed:29104511).
May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles.

Aging Source: Ensembl
Brain development Source: Ensembl
Calcium ion export across plasma membrane Source: SynGO-UCL
Cellular calcium ion homeostasis Source: GO_Central
Cellular response to corticosterone stimulus Source: Ensembl
Cellular response to vitamin D Source: Ensembl
Ion transmembrane transport Source: Reactome
Negative regulation of cytokine production Source: UniProtKB
Negative regulation of cytosolic calcium ion concentration Source: UniProtKB
Neural retina development Source: Ensembl
Positive regulation of bone mineralization Source: UniProtKB
Positive regulation of calcium ion transport Source: UniProtKB
Regulation of blood pressure Source: UniProtKB
Regulation of cardiac conduction Source: Reactome
Regulation of cellular response to insulin stimulus Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: SynGO-UCL
Regulation of vascular associated smooth muscle contraction Source: UniProtKB
Response to cold Source: Ensembl

Cell membrane; Basolateral cell membrane; Presynaptic cell membrane; Synapse; Synaptic vesicle membrane. Colocalizes with SV2A in photoreceptor synaptic terminals. Colocalizes with NPTN to the immunological synapse. Colocalizes with EPB41 to the basolateral membrane in enterocyte. Preferentially sorted to recycling synaptic vesicles.

Cytoplasmic: 2-105 aa
Helical: 106-126 aa
Extracellular: 127-154 aa
Helical: 155-175 aa
Cytoplasmic: 176-366 aa
Helical: 367-386 aa
Extracellular: 387-418 aa
Helical: 419-439 aa
Cytoplasmic: 440-855 aa
Helical: 856-876 aa
Extracellular: 877-882 aa
Helical: 883-903 aa
Cytoplasmic: 904-927 aa
Helical: 928-948 aa
Extracellular: 949-971 aa
Helical: 972-991 aa
Cytoplasmic: 992-1005 aa
Helical: 1006-1027 aa
Extracellular: 1028-1039 aa
Helical: 1040-1060 aa
Cytoplasmic: 1061-1220 aa