BAMBI

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq]

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)

Negatively regulates TGF-beta signaling.

Cell migration Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: ARUK-UCL
Negative regulation of osteoblast differentiation Source: ARUK-UCL
Negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Regulation of cell shape Source: BHF-UCL
Transforming growth factor beta receptor signaling pathway Source: GO_Central

Membrane

Extracellular: 21-152 aa
Helical: 153-173 aa
Cytoplasmic: 174-260 aa