Mouse Recombinant BAMBI protein, His Tag (V2LY-0526-LY7858)

Name: Mouse Recombinant BAMBI protein, His Tag
SKU: V2LY-0526-LY7858
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant BAMBI protein, His Tag consist of Amino Acid: 1-152 and predicts a molecular mass of 15.4 kDa.

Molecule Mass

15.4 kDa

Sequence

Amino Acid: 1-152

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)

Function

Negatively regulates TGF-beta signaling.

Biological Process

Cell migration Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: ARUK-UCL
Negative regulation of osteoblast differentiation Source: ARUK-UCL
Negative regulation of transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
Positive regulation of protein binding Source: BHF-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Regulation of cell shape Source: BHF-UCL
Transforming growth factor beta receptor signaling pathway Source: GO_Central

Cellular Location

Membrane

Topology

Extracellular: 21-152 aa
Helical: 153-173 aa
Cytoplasmic: 174-260 aa

Chen, X., Zhao, C., Xu, Y., Huang, K., Wang, Y., Wang, X., ... & Yu, T. (2021). Adipose-specific BMP and activin membrane-bound inhibitor (BAMBI) deletion promotes adipogenesis by accelerating ROS production. Journal of Biological Chemistry, 296.

Nangaku, M. (2020). Schlöndorff and Lee revealed crosstalk between glomerular cells and a role of BAMBI in diabetic kidney disease. Kidney International, 98(3), 539-541.

Alvarez, P., Augustín, J. J., Tamayo, E., Iglesias, M., Acinas, O., Mendiguren, M. A., ... & Merino, R. (2020). Therapeutic Effects of Anti–Bone Morphogenetic Protein and Activin Membrane‐Bound Inhibitor Treatment in Psoriasis and Arthritis. Arthritis & Rheumatology, 72(9), 1547-1558.

Yao, X., Yu, T., Xi, F., Xu, Y., Ma, L., Pan, X., ... & Xie, L. (2019). BAMBI shuttling between cytosol and membrane is required for skeletal muscle development and regeneration. Biochemical and biophysical research communications, 509(1), 125-132.

Wang, D., Chen, X., & Zhang, R. (2018). BAMBI promotes macrophage proliferation and differentiation in gliomas. Molecular medicine reports, 17(3), 3960-3966.

Hernandez, H., Millar, J. C., Curry, S. M., Clark, A. F., & McDowell, C. M. (2018). BMP and activin membrane bound inhibitor regulates the extracellular matrix in the trabecular meshwork. Investigative ophthalmology & visual science, 59(5), 2154-2166.

Yu, W., & Chai, H. (2017). Inhibition of BAMBI reduces the viability and motility of colon cancer via activating TGF‑β/Smad pathway in vitro and in vivo. Oncology letters, 14(4), 4793-4799.

Bai, L., Chu, G., Wang, W., Xiang, A., & Yang, G. (2017). BAMBI promotes porcine granulosa cell steroidogenesis involving TGF-β signaling. Theriogenology, 100, 24-31.

Wang, X., Li, M., Hu, M., Wei, P., & Zhu, W. (2017). BAMBI overexpression together with β-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-β/Smad2/3 pathway. Oncology reports, 37(5), 3046-3054.

Yang, Y., Guo, C., Liao, B., Cao, J., Liang, C., & He, X. (2017). BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury. International journal of molecular medicine, 39(2), 423-429.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant BAMBI protein, His Tag (CAT#: V2LY-0526-LY2296)

Mouse Recombinant BAMBI protein, hFc Tag (CAT#: V2LY-0526-LY7857)

Human BAMBI ELISA Kit (CAT#: V2LY-0626-LY2601)

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Mouse Recombinant BAMBI protein, hFc Tag (CAT#: V2LY-0526-LY7857)

Human Recombinant BAMBI protein, His Tag (CAT#: V2LY-0526-LY2296)

Human BAMBI ELISA Kit (CAT#: V2LY-0626-LY2601)

Mouse Anti-BAMBI Recombinant Antibody (CBYY-1680) (CAT#: CBMAB-2029-YY)

Mouse Anti-BAMBI Recombinant Antibody (CBYY-2032) (CAT#: CBMAB-2381-YY)

Mouse Anti-BAMBI Recombinant Antibody (CBYY-0185) (CAT#: CBMAB-0186-YY)

Mouse Anti-BAMBI Recombinant Antibody (CBYY-0181) (CAT#: CBMAB-0182-YY)

Mouse Anti-BAMBI Recombinant Antibody (3C1-1D1) (CAT#: CBMAB-A0706-LY)

Mouse Anti-BAMBI Recombinant Antibody (CBYY-0180) (CAT#: CBMAB-0181-YY)

Isotype control

For research use only. Not intended for any clinical use.

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