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BCL2L2

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
Full Name
BCL2 Like 2
Function
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Biological Process
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
Spermatogenesis Source: ProtInc
Cellular Location
Mitochondrion membrane; Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
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Anti-BCL2L2 antibodies

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Mouse Anti-BCL2L2 Recombinant Antibody (CBYY-1692) (CBMAB-2041-YY)

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Target: BCL2L2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-1692
Application*: N
Functional Assay
Datasheet SDS

Mouse Anti-BCL2L2 Recombinant Antibody (CBYY-0427) (CBMAB-0429-YY)

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Target: BCL2L2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-0427
Application*: E, WB
Datasheet SDS

Mouse Anti-BCL2L2 Antibody Recombinant (1028) (CBMAB-1028CQ)

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Target: BCL2L2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1028
Application*: WB
Datasheet SDS

Mouse Anti-BCL2L2 Recombinant Antibody (CBT4556) (V2LY-0625-LY732)

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Target: BCL2L2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4556
Application*: F
Datasheet SDS

Mouse Anti-BCL2L2 Recombinant Antibody (CBT2447) (V2LY-0625-LY722)

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Target: BCL2L2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT2447
Application*: IH, IC, F
Datasheet SDS

Rabbit Anti-BCL2L2 Recombinant Antibody (EG378) (CBMAB-EN418-LY)

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Target: BCL2L2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG378
Application*: E
Datasheet SDS

Mouse Anti-BCL2L2 Recombinant Antibody (2E4) (CBMAB-1207-CN)

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Target: BCL2L2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 2E4
Application*: WB, E, IP
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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