Human Recombinant BCL2L2 protein, His Tag (V2LY-0526-LY2315)

Name: Human Recombinant BCL2L2 protein, His Tag
SKU: V2LY-0526-LY2315
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant BCL2L2 protein, His Tag consist of Amino Acid: 1-172 and predicts a molecular mass of 20 kDa.

Molecule Mass

20 kDa

Sequence

Amino Acid: 1-172

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, Glycerol, Trehalose, EDTA

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

BCL2 Like 2

Function

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

Biological Process

Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
Spermatogenesis Source: ProtInc

Cellular Location

Mitochondrion membrane; Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Li, Y., Li, X., Wang, L., Han, N., & Yin, G. (2021). miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells. Biotechnology Letters, 43(2), 353-367.

Yu, T., Yu, J., Lu, L., Zhang, Y., Zhou, Y., Zhou, Y., ... & Wang, B. (2021). MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis. Cellular Oncology, 1-14.

Zhang, M., & Cheng, K. (2021). Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis. Experimental Eye Research, 206, 108543.

Liu, H. N., Tang, X. M., Wang, X. Q., Gao, J., Li, N., Wang, Y. Y., & Xia, H. F. (2020). MiR-93 inhibits trophoblast cell proliferation and promotes cell apoptosis by targeting BCL2L2 in recurrent spontaneous abortion. Reproductive Sciences, 27(1), 152-162.

Ming, M., Ying, M., & Ling, M. (2019). miRNA‑125a‑5p inhibits hepatocellular carcinoma cell proliferation and induces apoptosis by targeting TP53 regulated inhibitor of apoptosis 1 and Bcl‑2‑like‑2 protein. Experimental and therapeutic medicine, 18(2), 1196-1202.

Zhang, N., Meng, X., Mei, L., Hu, J., Zhao, C., & Chen, W. (2018). The long non-coding RNA SNHG1 attenuates cell apoptosis by regulating miR-195 and BCL2-like protein 2 in human cardiomyocytes. Cellular Physiology and Biochemistry, 50(3), 1029-1040.

Wang, C., Zhou, B., Liu, M., Liu, Y., & Gao, R. (2017). miR-126-5p restoration promotes cell apoptosis in cervical cancer by targeting Bcl2l2. Oncology research, 25(4), 463.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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