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Rabbit Anti-BCL2L2 Recombinant Antibody (EG378) (CBMAB-EN418-LY)

The product is antibody recognizes BCL2L2 . The antibody EG378 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000.
See all BCL2L2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG378
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human Bcl-W / BCL2L2 protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BCL2 Like 2
Introduction
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
Entrez Gene ID
Human599
Mouse12050
Rat60434
UniProt ID
HumanQ92843
MouseP70345
RatO88996
Alternative Names
BCL2 Like 2; Protein Phosphatase 1, Regulatory Subunit 51; Bcl2-L-2; BCLW; Apoptosis Regulator Bcl-W; Apoptosis Regulator BCL-W;
Function
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Biological Process
Extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
Intrinsic apoptotic signaling pathway in response to DNA damage Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of intrinsic apoptotic signaling pathway Source: GO_Central
Spermatogenesis Source: ProtInc
Cellular Location
Mitochondrion membrane; Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

Li, Y., Li, X., Wang, L., Han, N., & Yin, G. (2021). miR-375-3p contributes to hypoxia-induced apoptosis by targeting forkhead box P1 (FOXP1) and Bcl2 like protein 2 (Bcl2l2) in rat cardiomyocyte h9c2 cells. Biotechnology Letters, 43(2), 353-367.

Yu, T., Yu, J., Lu, L., Zhang, Y., Zhou, Y., Zhou, Y., ... & Wang, B. (2021). MT1JP-mediated miR-24-3p/BCL2L2 axis promotes Lenvatinib resistance in hepatocellular carcinoma cells by inhibiting apoptosis. Cellular Oncology, 1-14.

Zhang, M., & Cheng, K. (2021). Long non-coding RNA KCNQ1OT1 promotes hydrogen peroxide-induced lens epithelial cell apoptosis and oxidative stress by regulating miR-223-3p/BCL2L2 axis. Experimental Eye Research, 206, 108543.

Liu, H. N., Tang, X. M., Wang, X. Q., Gao, J., Li, N., Wang, Y. Y., & Xia, H. F. (2020). MiR-93 inhibits trophoblast cell proliferation and promotes cell apoptosis by targeting BCL2L2 in recurrent spontaneous abortion. Reproductive Sciences, 27(1), 152-162.

Ming, M., Ying, M., & Ling, M. (2019). miRNA‑125a‑5p inhibits hepatocellular carcinoma cell proliferation and induces apoptosis by targeting TP53 regulated inhibitor of apoptosis 1 and Bcl‑2‑like‑2 protein. Experimental and therapeutic medicine, 18(2), 1196-1202.

Zhang, N., Meng, X., Mei, L., Hu, J., Zhao, C., & Chen, W. (2018). The long non-coding RNA SNHG1 attenuates cell apoptosis by regulating miR-195 and BCL2-like protein 2 in human cardiomyocytes. Cellular Physiology and Biochemistry, 50(3), 1029-1040.

Wang, C., Zhou, B., Liu, M., Liu, Y., & Gao, R. (2017). miR-126-5p restoration promotes cell apoptosis in cervical cancer by targeting Bcl2l2. Oncology research, 25(4), 463.

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For research use only. Not intended for any clinical use.

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