CAND1

CAND1 (Cullin Associated And Neddylation Dissociated 1) is a Protein Coding gene. Diseases associated with CAND1 include Familial Hypertension. Among its related pathways are Innate Immune System and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include binding and TBP-class protein binding. An important paralog of this gene is CAND2.
Full Name
Cullin Associated And Neddylation Dissociated 1
Function
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Biological Process
Cell differentiation Source: UniProtKB
Cellular iron ion homeostasis Source: Reactome
Negative regulation of catalytic activity Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: Ensembl
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB
SCF complex assembly Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Predominantly cytoplasmic.
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Anti-CAND1 antibodies

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Mouse Anti-CAND1 Recombinant Antibody (4D10) (CBMAB-CP0090-LY)

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Target: CAND1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: 4D10
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-CAND1 Recombinant Antibody (2D7) (CBMAB-A1084-LY)

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Target: CAND1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: 2D7
Application*: WB, E
Datasheet SDS

Mouse Anti-CAND1 Recombinant Antibody (CBLC078-LY) (CBMAB-C9679-LY)

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Target: CAND1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLC078-LY
Application*: E, IF, IP, WB, P
Datasheet SDS

Mouse Anti-CAND1 Recombinant Antibody (CBYJT-1055) (CBMAB-T0065-YJ)

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Target: CAND1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat, Horse, Cattle, Pig
Clone: CBYJT-1055
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-CAND1 Recombinant Antibody (5F2) (CBMAB-C7564-LY)

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Target: CAND1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 5F2
Application*: E, WB
Datasheet SDS

Mouse Anti-CAND1 Recombinant Antibody (5D7) (CBMAB-C7468-LY)

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Target: CAND1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D7
Application*: WB, IF, P, E
Datasheet SDS

Mouse Anti-CAND1 Recombinant Antibody (CBXC-0057) (CBMAB-C5502-CQ)

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Target: CAND1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-0057
Application*: E, IF, IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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