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Mouse Anti-CAND1 Recombinant Antibody (4D10) (CBMAB-CP0090-LY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
4D10
Application
WB, ELISA, IF
Immunogen
CAND1 (NP_060918, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Cullin Associated And Neddylation Dissociated 1
Introduction
CAND1 (Cullin Associated And Neddylation Dissociated 1) is a Protein Coding gene. Diseases associated with CAND1 include Familial Hypertension. Among its related pathways are Innate Immune System and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include binding and TBP-class protein binding. An important paralog of this gene is CAND2.
Entrez Gene ID
Human55832
Mouse71902
Rat117152
Monkey716184
Chicken417837
Dog474437
Pig100514460
Guinea Pig100734932
UniProt ID
HumanQ86VP6
MouseQ6ZQ38
RatP97536
MonkeyG7PHZ3
ChickenF1NHL2
DogQ8WMD0
PigF2Z5R6
Guinea PigH0UX20
Alternative Names
Cullin Associated And Neddylation Dissociated 1; TBP-Interacting Protein Of 120 KDa A; P120 CAND1; TIP120A; TIP120; Cullin-Associated And Neddylation-Dissociated Protein 1;
Function
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Biological Process
Cell differentiation Source: UniProtKB
Cellular iron ion homeostasis Source: Reactome
Negative regulation of catalytic activity Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: Ensembl
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB
SCF complex assembly Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Predominantly cytoplasmic.

Pan, Z., Li, X., Zhang, Y., Zhao, Y., Zhou, Y., Han, Q., ... & Yang, B. (2021). Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.

Cheng, W., Yin, S., Tu, Y., Mei, H., Wang, Y., & Yang, Y. (2020). SlCAND1, encoding cullin-associated Nedd8-dissociated protein 1, regulates plant height, flowering time, seed germination, and root architecture in tomato. Plant molecular biology, 102(4), 537-551.

Kajiho, H., Yamamoto, Y., & Sakisaka, T. (2019). CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. Scientific reports, 9(1), 1-16.

Che, Z., Liu, F., Zhang, W., McGrath, M., Hou, D., Chen, P., ... & Yang, D. (2018). Targeting CAND1 promotes caspase-8/RIP1-dependent apoptosis in liver cancer cells. American journal of translational research, 10(5), 1357.

Nakashima, K., Takeuchi, S., Iwama, S., Kiyota, A., Yasuda, Y., Iwata, N., ... & Sugimura, Y. (2018). Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells. endocrine journal, EJ17-0399.

Buonanno, M., Langella, E., Zambrano, N., Succoio, M., Sasso, E., Alterio, V., ... & De Simone, G. (2017). Disclosing the interaction of carbonic anhydrase IX with cullin-associated NEDD8-dissociated protein 1 by molecular modeling and integrated binding measurements. ACS chemical biology, 12(6), 1460-1465.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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