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Mouse Anti-CAND1 Recombinant Antibody (CBXC-0057) (CBMAB-C5502-CQ)

This product is a mouse antibody that recognizes CAND1. The antibody CBXC-0057 can be used for immunoassay techniques such as: IF, ELISA, WB.
See all CAND1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-0057
Antibody Isotype
IgG3, κ
Application
IF, ELISA, WB

Basic Information

Immunogen
CAND1 (NP_060918, 1 a.a.-100 a.a) partial recombinant protein with GST tag.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cullin Associated And Neddylation Dissociated 1
Introduction
CAND1 (Cullin Associated And Neddylation Dissociated 1) is a Protein Coding gene. Diseases associated with CAND1 include Familial Hypertension. Among its related pathways are Innate Immune System and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include binding and TBP-class protein binding. An important paralog of this gene is CAND2.
Entrez Gene ID
Human55832
Mouse71902
Rat117152
UniProt ID
HumanQ86VP6
MouseQ6ZQ38
RatP97536
Alternative Names
Cullin Associated And Neddylation Dissociated 1; TBP-Interacting Protein Of 120 KDa A; P120 CAND1; TIP120A; TIP120; Cullin-Associated And Neddylation-Dissociated Protein 1;
Function
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Biological Process
Cell differentiation Source: UniProtKB
Cellular iron ion homeostasis Source: Reactome
Negative regulation of catalytic activity Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: Ensembl
Post-translational protein modification Source: Reactome
Protein ubiquitination Source: UniProtKB
SCF complex assembly Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm. Predominantly cytoplasmic.

Pan, Z., Li, X., Zhang, Y., Zhao, Y., Zhou, Y., Han, Q., ... & Yang, B. (2021). Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.

Cheng, W., Yin, S., Tu, Y., Mei, H., Wang, Y., & Yang, Y. (2020). SlCAND1, encoding cullin-associated Nedd8-dissociated protein 1, regulates plant height, flowering time, seed germination, and root architecture in tomato. Plant molecular biology, 102(4), 537-551.

Kajiho, H., Yamamoto, Y., & Sakisaka, T. (2019). CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. Scientific reports, 9(1), 1-16.

Che, Z., Liu, F., Zhang, W., McGrath, M., Hou, D., Chen, P., ... & Yang, D. (2018). Targeting CAND1 promotes caspase-8/RIP1-dependent apoptosis in liver cancer cells. American journal of translational research, 10(5), 1357.

Nakashima, K., Takeuchi, S., Iwama, S., Kiyota, A., Yasuda, Y., Iwata, N., ... & Sugimura, Y. (2018). Cullin-associated NEDD8-dissociated protein 1, a novel interactor of rabphilin-3A, deubiquitylates rabphilin-3A and regulates arginine vasopressin secretion in PC12 cells. endocrine journal, EJ17-0399.

Buonanno, M., Langella, E., Zambrano, N., Succoio, M., Sasso, E., Alterio, V., ... & De Simone, G. (2017). Disclosing the interaction of carbonic anhydrase IX with cullin-associated NEDD8-dissociated protein 1 by molecular modeling and integrated binding measurements. ACS chemical biology, 12(6), 1460-1465.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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