CCL23
CCL23 (C-C Motif Chemokine Ligand 23) is a Protein Coding gene. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL15.
Full Name
C-C Motif Chemokine Ligand 23
Function
Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small-inducible cytokine A23.
Biological Process
Cell-cell signaling Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Negative regulation of C-C chemokine binding Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Signal transduction Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Negative regulation of C-C chemokine binding Source: UniProtKB
Negative regulation of cell population proliferation Source: ProtInc
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Secreted
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Anti-CCL23 antibodies
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CompareTarget: CCL23
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 103952
Application*: E, WB
Target: CCL23
Expressed Host: Yeast
Sequence: Amino Acid: 46-120
Tag: His Tag
Target: CCL23
Expressed Host: E. coli
Sequence: Amino Acid: 22-120
Tag: His Tag
Target: CCL23
Expressed Host: E. coli
Sequence: Amino Acid: 22-120
Target: CCL23
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0964
Application*: E
Target: CCL23
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0963
Application*: WB, N
Target: CCL23
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0934
Application*: E, WB
Target: CCL23
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-0933
Application*: E, WB, IP, IF
Target: CCL23
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 69523
Application*: E
Target: CCL23
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 03
Application*: E
Target: CCL23
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 007
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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