Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

CD300A

CD300A (CD300a Molecule) is a Protein Coding gene. Diseases associated with CD300A include Kabuki Syndrome 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include phosphatidylserine binding and signaling receptor activity. An important paralog of this gene is CD300C.
Full Name
CD300a Molecule
Function
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027).
Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).
Biological Process
Cell adhesion Source: UniProtKB-KW
Negative regulation of activation of Janus kinase activity Source: UniProtKB
Negative regulation of B cell proliferation Source: UniProtKB
Negative regulation of B cell receptor signaling pathway Source: UniProtKB
Negative regulation of eosinophil activation Source: UniProtKB
Negative regulation of eosinophil migration Source: UniProtKB
Negative regulation of fibroblast proliferation Source: UniProtKB
Negative regulation of MAP kinase activity Source: UniProtKB
Negative regulation of mast cell activation involved in immune response Source: UniProtKB
Negative regulation of mast cell degranulation Source: UniProtKB
Negative regulation of MyD88-dependent toll-like receptor signaling pathway Source: UniProtKB
Negative regulation of neutrophil activation Source: UniProtKB
Negative regulation of NK T cell activation Source: UniProtKB
Negative regulation of phagocytosis, engulfment Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of phosphoprotein phosphatase activity Source: UniProtKB
Regulation of immune response Source: Reactome
Regulation of T cell receptor signaling pathway Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 18-180
Helical: 181-201
Cytoplasmic: 202-299
PTM
Phosphorylated on tyrosine.
N-glycosylated.

Anti-CD300A antibodies

+ Filters
Loading...
Target: CD300A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-260
Application*: F, WB
Target: CD300A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 172224
Application*: F
Target: CD300A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0078
Application*: WB
Target: CD300A
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 232612
Application*: WB, F
Target: CD300A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1
Application*: F
Target: CD300A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: P192
Application*: F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Online Inquiry