CD300A

CD300A (CD300a Molecule) is a Protein Coding gene. Diseases associated with CD300A include Kabuki Syndrome 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include phosphatidylserine binding and signaling receptor activity. An important paralog of this gene is CD300C.

Full Name

CD300a Molecule

Function

Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027).
Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).

Biological Process

Cell adhesion Source: UniProtKB-KW
Negative regulation of activation of Janus kinase activity Source: UniProtKB
Negative regulation of B cell proliferation Source: UniProtKB
Negative regulation of B cell receptor signaling pathway Source: UniProtKB
Negative regulation of eosinophil activation Source: UniProtKB
Negative regulation of eosinophil migration Source: UniProtKB
Negative regulation of fibroblast proliferation Source: UniProtKB
Negative regulation of MAP kinase activity Source: UniProtKB
Negative regulation of mast cell activation involved in immune response Source: UniProtKB
Negative regulation of mast cell degranulation Source: UniProtKB
Negative regulation of MyD88-dependent toll-like receptor signaling pathway Source: UniProtKB
Negative regulation of neutrophil activation Source: UniProtKB
Negative regulation of NK T cell activation Source: UniProtKB
Negative regulation of phagocytosis, engulfment Source: UniProtKB
Neutrophil degranulation Source: Reactome
Positive regulation of phosphoprotein phosphatase activity Source: UniProtKB
Regulation of immune response Source: Reactome
Regulation of T cell receptor signaling pathway Source: UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 18-180
Helical: 181-201
Cytoplasmic: 202-299

PTM

Phosphorylated on tyrosine.
N-glycosylated.