CD84

CD84 (CD84 Molecule) is a Protein Coding gene. Diseases associated with CD84 include Leukemia, Chronic Lymphocytic. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is LY9.

CD84 Molecule

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity).
Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity).
In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234).
In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).
Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592).

Adaptive immune response Source: UniProtKB-KW
Autophagy Source: UniProtKB-KW
Defense response Source: ProtInc
Homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
Innate immune response Source: UniProtKB-KW
Leukocyte migration Source: Reactome
Negative regulation of granulocyte macrophage colony-stimulating factor production Source: UniProtKB
Negative regulation of interleukin-18 production Source: UniProtKB
Negative regulation of mast cell activation Source: UniProtKB
Negative regulation of mast cell degranulation Source: UniProtKB
Regulation of store-operated calcium entry Source: UniProtKB

Cell membrane

Extracellular: 22-225
Helical: 226-246
Cytoplasmic: 247-345

Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A is dependent of tyrosine phosphorylation of its cytoplasmic domain. Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. Phosphorylated on tyrosine residues upon high affinity immunoglobulin epsilon receptor aggregation in mast cells.
N-glycosylated.