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Mouse Anti-CD84 Recombinant Antibody (CBXC-0276) (CBMAB-C5867-CQ)

This product is a mouse antibody that recognizes CD84. The antibody CBXC-0276 can be used for immunoassay techniques such as: ELISA, WB.
See all CD84 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0276
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD84 Molecule
Introduction
CD84 (CD84 Molecule) is a Protein Coding gene. Diseases associated with CD84 include Leukemia, Chronic Lymphocytic. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Gene Ontology (GO) annotations related to this gene include receptor activity. An important paralog of this gene is LY9.
Entrez Gene ID
8832
UniProt ID
Q9UIB8
Alternative Names
CD84 Molecule; Signaling Lymphocytic Activation Molecule 5; Leukocyte Differentiation Antigen CD84; CD84 Antigen (Leukocyte Antigen); Cell Surface Antigen MAX.3; Hly9-Beta; SLAMF5; Leucocyte Differentiation Antigen CD84;
Function
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity).
Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity).
In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234).
In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).
Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Autophagy Source: UniProtKB-KW
Defense response Source: ProtInc
Homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
Innate immune response Source: UniProtKB-KW
Leukocyte migration Source: Reactome
Negative regulation of granulocyte macrophage colony-stimulating factor production Source: UniProtKB
Negative regulation of interleukin-18 production Source: UniProtKB
Negative regulation of mast cell activation Source: UniProtKB
Negative regulation of mast cell degranulation Source: UniProtKB
Regulation of store-operated calcium entry Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-225
Helical: 226-246
Cytoplasmic: 247-345
PTM
Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A is dependent of tyrosine phosphorylation of its cytoplasmic domain. Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation. Phosphorylated on tyrosine residues upon high affinity immunoglobulin epsilon receptor aggregation in mast cells.
N-glycosylated.

Tong, D., Zhao, Y., Tang, Y., Ma, J., Wang, Z., & Li, C. (2021). Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84. Bioengineered, (just-accepted).

Lewinsky, H., Gunes, E. G., David, K., Radomir, L., Kramer, M. P., Pellegrino, B., ... & Shachar, I. (2021). CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma. JCI insight, 6(4).

Schuhmann, M. K., Stoll, G., Bieber, M., Vögtle, T., Hofmann, S., Klaus, V., ... & Stegner, D. (2020). CD84 links T cell and platelet activity in cerebral thrombo-inflammation in acute stroke. Circulation research, 127(8), 1023-1035.

Barak, A. F., Lewinsky, H., Perpinial, M., Huber, V., Radomir, L., Kramer, M. P., ... & Shachar, I. (2020). Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner. Oncogene, 39(9), 1997-2008.

Cuenca, M., Sintes, J., Lányi, Á., & Engel, P. (2019). CD84 cell surface signaling molecule: An emerging biomarker and target for cancer and autoimmune disorders. Clinical Immunology, 204, 43-49.

Lewinsky, H., Barak, A. F., Huber, V., Kramer, M. P., Radomir, L., Sever, L., ... & Shachar, I. (2018). CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia. The Journal of clinical investigation, 128(12), 5465-5478.

Wang, T. T., Pham, Q., & Kim, Y. S. (2018). Elucidating the role of CD84 and AHR in modulation of LPS-induced cytokines production by cruciferous vegetable-derived compounds indole-3-carbinol and 3, 3′-diindolylmethane. International journal of molecular sciences, 19(2), 339.

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For research use only. Not intended for any clinical use.

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