CDX1
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
Full Name
Caudal Type Homeobox 1
Function
Plays a role in transcriptional regulation (PubMed:24623306).
Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306).
Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306).
Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Biological Process
Animal organ morphogenesis Source: GO_Central
Anterior/posterior axis specification Source: GO_Central
Bone morphogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of somitogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Anterior/posterior axis specification Source: GO_Central
Bone morphogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of somitogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
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Anti-CDX1 antibodies
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Target: CDX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E9
Application*: E, WB
Target: CDX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 3A3
Application*: IF, E
Target: CDX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 2D8
Application*: WB, IF, E
Target: CDX1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 1F12
Application*: WB, IF, E
Target: CDX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 11E10
Application*: E, WB, IF
Target: CDX1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3287
Application*: WB
Target: CDX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1549
Application*: IF, WB
Target: CDX1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-2478
Application*: WB
Target: CDX1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: CBXC-2380
Application*: WB, IF, E
Target: CDX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: CBFYC-1660
Application*: IF, E
Target: CDX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1659
Application*: WB, IF, E, IP
Target: CDX1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-0244
Application*: IF, P
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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