Mouse Anti-CDX1 Recombinant Antibody (1E9) (CBMAB-C3993-LY)

Name: Mouse Anti-CDX1 Recombinant Antibody (1E9)
SKU: CBMAB-C3993-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1E9

Application

ELISA, WB

Immunogen

CDX1 full length recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Caudal Type Homeobox 1

Introduction

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]

Entrez Gene ID

1044

UniProt ID

P47902

Alternative Names

Caudal Type Homeobox 1; Caudal Type Homeo Box Transcription Factor 1; Caudal-Type Homeobox Protein 1;

Function

Plays a role in transcriptional regulation (PubMed:24623306).
Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306).
Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).

Biological Process

Animal organ morphogenesis Source: GO_Central
Anterior/posterior axis specification Source: GO_Central
Bone morphogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of somitogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Lei, D., Sun, H., & Zhang, B. (2021). MiR-24 Promotes Cell Growth in Human Glioma by CDX1/PI3K/Akt Signaling Pathway. Cancer Biotherapy & Radiopharmaceuticals, 36(7), 588-599.

Kim, K., Noh, S., Cheong, J. H., & Kim, H. (2021). CDX-1/CDX-2 Expression Is a Favorable Prognostic Factor in Epstein-Barr Virus-Negative, Mismatch Repair-Proficient Advanced Gastric Cancers. Gut and Liver, 15(5), 694.

Ma, L., Cao, Y., Hu, J. J., & Chu, M. L. (2020). Casein kinase 2 interacting protein 1 positively regulates caudal-related homeobox 1 in intestinal-type gastric cancer. Chinese medical journal, 133(2), 154.

Samadani, A. A., Nikbakhsh, N., Taheri, H., Shafaee, S., Fattahi, S., Langroudi, M. P., ... & Akhavan-Niaki, H. (2019). CDX1/2 and KLF5 expression and epigenetic modulation of sonic hedgehog signaling in gastric adenocarcinoma. Pathology & Oncology Research, 25(3), 1215-1222.

Nakayama, C., Yamamichi, N., Tomida, S., Takahashi, Y., Kageyama‐Yahara, N., Sakurai, K., ... & Koike, K. (2018). Transduced caudal‐type homeobox (CDX) 2/CDX 1 can induce growth inhibition on CDX‐deficient gastric cancer by rapid intestinal differentiation. Cancer science, 109(12), 3853-3864.

Zheng, R., Lin, S., Guan, L., Yuan, H., Liu, K., Liu, C., ... & Zhang, R. (2018). Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. Biochemical and biophysical research communications, 498(4), 1002-1008.

Kiani, S., Akhavan-Niaki, H., Fattahi, S., Kavoosian, S., Jelodar, N. B., Bagheri, N., & Zarrini, H. N. (2018). Purified sulforaphane from broccoli (Brassica oleracea var. italica) leads to alterations of CDX1 and CDX2 expression and changes in miR-9 and miR-326 levels in human gastric cancer cells. Gene, 678, 115-123.

Yang, L., Li, C., Liang, F., Fan, Y., & Zhang, S. (2017). MiRNA-155 promotes proliferation by targeting caudal-type homeobox 1 (CDX1) in glioma cells. Biomedicine & Pharmacotherapy, 95, 1759-1764.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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