Sign in or Register   Sign in or Register
  |  

Mouse Anti-CDX1 Recombinant Antibody (3A3) (CBMAB-1349-CN)

This product is a mouse antibody that recognizes CDX1 of human. The antibody 3A3 can be used for immunoassay techniques such as: IF, ELISA.
See all CDX1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A3
Antibody Isotype
IgG2a, Κ
Application
IF, ELISA

Basic Information

Immunogen
CDX1 (NP_001795, aa. 126-215) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1x PBS,  pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Caudal Type Homeobox 1
Introduction
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. This protein plays a role in transcriptional regulation. It binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306). It could play a role in the terminal differentiation of the intestine.
Entrez Gene ID
1044
UniProt ID
P47902
Alternative Names
homeobox protein CDX-1; caudal type homeo box transcription factor 1; caudal type homeobox transcription factor 1; caudal-type homeobox protein 1; caudal-type homeobox protein CDX1
Function
Plays a role in transcriptional regulation (PubMed:24623306).
Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306).
Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Biological Process
Animal organ morphogenesis Source: GO_Central
Anterior/posterior axis specification Source: GO_Central
Bone morphogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of somitogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus

Lei, D., Sun, H., & Zhang, B. (2021). MiR-24 Promotes Cell Growth in Human Glioma by CDX1/PI3K/Akt Signaling Pathway. Cancer Biotherapy & Radiopharmaceuticals, 36(7), 588-599.

Kim, K., Noh, S., Cheong, J. H., & Kim, H. (2021). CDX-1/CDX-2 Expression Is a Favorable Prognostic Factor in Epstein-Barr Virus-Negative, Mismatch Repair-Proficient Advanced Gastric Cancers. Gut and Liver, 15(5), 694.

Ma, L., Cao, Y., Hu, J. J., & Chu, M. L. (2020). Casein kinase 2 interacting protein 1 positively regulates caudal-related homeobox 1 in intestinal-type gastric cancer. Chinese medical journal, 133(2), 154.

Samadani, A. A., Nikbakhsh, N., Taheri, H., Shafaee, S., Fattahi, S., Langroudi, M. P., ... & Akhavan-Niaki, H. (2019). CDX1/2 and KLF5 expression and epigenetic modulation of sonic hedgehog signaling in gastric adenocarcinoma. Pathology & Oncology Research, 25(3), 1215-1222.

Nakayama, C., Yamamichi, N., Tomida, S., Takahashi, Y., Kageyama‐Yahara, N., Sakurai, K., ... & Koike, K. (2018). Transduced caudal‐type homeobox (CDX) 2/CDX 1 can induce growth inhibition on CDX‐deficient gastric cancer by rapid intestinal differentiation. Cancer science, 109(12), 3853-3864.

Zheng, R., Lin, S., Guan, L., Yuan, H., Liu, K., Liu, C., ... & Zhang, R. (2018). Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. Biochemical and biophysical research communications, 498(4), 1002-1008.

Kiani, S., Akhavan-Niaki, H., Fattahi, S., Kavoosian, S., Jelodar, N. B., Bagheri, N., & Zarrini, H. N. (2018). Purified sulforaphane from broccoli (Brassica oleracea var. italica) leads to alterations of CDX1 and CDX2 expression and changes in miR-9 and miR-326 levels in human gastric cancer cells. Gene, 678, 115-123.

Yang, L., Li, C., Liang, F., Fan, Y., & Zhang, S. (2017). MiRNA-155 promotes proliferation by targeting caudal-type homeobox 1 (CDX1) in glioma cells. Biomedicine & Pharmacotherapy, 95, 1759-1764.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CDX1 Recombinant Antibody (3A3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare