CHD1L

This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]

Full Name

Chromodomain Helicase DNA Binding Protein 1 Like

Function

DNA helicase which plays a role in chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220653).
Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair (PubMed:19661379).
Able to catalyze nucleosome sliding in an ATP-dependent manner (PubMed:19661379).
Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (PubMed:19661379, PubMed:29220653).

Biological Process

Cellular response to DNA damage stimulus Source: UniProtKB
Chromatin remodeling Source: UniProtKB
DNA repair Source: UniProtKB
Global genome nucleotide-excision repair Source: Reactome
Nucleotide-excision repair, DNA duplex unwinding Source: Reactome
Nucleotide-excision repair, DNA incision Source: Reactome
Nucleotide-excision repair, DNA incision, 3'-to lesion Source: Reactome
Nucleotide-excision repair, DNA incision, 5'-to lesion Source: Reactome
Nucleotide-excision repair, preincision complex assembly Source: Reactome
Nucleotide-excision repair, preincision complex stabilization Source: Reactome

Cellular Location

Nucleus. Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.