Rabbit Anti-CHD1L Recombinant Antibody (CBFYC-1810) (CBMAB-C1872-FY)

Name: Rabbit Anti-CHD1L Recombinant Antibody (CBFYC-1810)
SKU: CBMAB-C1872-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYC-1810

Application

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 700-800 of human CHD1L.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 0.05% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Chromodomain Helicase DNA Binding Protein 1 Like

Introduction

This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers.

Entrez Gene ID

9557

UniProt ID

Q86WJ1

Alternative Names

Chromodomain Helicase DNA Binding Protein 1 Like; Amplified In Liver Cancer Protein 1; Amplified In Liver Cancer 1; ALC1; Chromodomain-Helicase-DNA-Binding Protein 1-Like; EC 3.6.4.12; EC 3.6.1; CHDL

Function

DNA helicase which plays a role in chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220653).
Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair (PubMed:19661379).
Able to catalyze nucleosome sliding in an ATP-dependent manner (PubMed:19661379).
Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (PubMed:19661379, PubMed:29220653).

Biological Process

Cellular response to DNA damage stimulus Source: UniProtKB
Chromatin remodeling Source: UniProtKB
DNA repair Source: UniProtKB
Global genome nucleotide-excision repair Source: Reactome
Nucleotide-excision repair, DNA duplex unwinding Source: Reactome
Nucleotide-excision repair, DNA incision Source: Reactome
Nucleotide-excision repair, DNA incision, 3'-to lesion Source: Reactome
Nucleotide-excision repair, DNA incision, 5'-to lesion Source: Reactome
Nucleotide-excision repair, preincision complex assembly Source: Reactome
Nucleotide-excision repair, preincision complex stabilization Source: Reactome

Cellular Location

Nucleus. Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.

Zhang, X., & Sun, Y. (2022). Chromodomain Helicase DNA Binding Protein 1-like, a negative regulator of Forkhead box O3a, promotes the proliferation and migration of Angiotensin II-induced vascular smooth muscle cells. Bioengineered, 13(2), 2597-2609.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Rabbit Anti-CHD1L Recombinant Antibody (CBWJC-2630) (CAT#: CBMAB-C3715WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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