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CLMP

This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]

Full Name

CXADR Like Membrane Protein

Function

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.

Biological Process

Digestive tract development Source: UniProtKB

Cellular Location

Cell membrane; Tight junction

Involvement in disease

Congenital short bowel syndrome (CSBS):
A disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life.

Topology

Extracellular: 19-235
Helical: 236-256
Cytoplasmic: 257-373

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Anti-CLMP antibodies

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Rabbit Anti-CLMP Recombinant Antibody (C4235) (CBMAB-C4235-LY)

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Target: CLMP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: C4235

Application*: E

Rat Recombinant ASAM protein, His Tag (V2LY-0526-LY9165)

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Target: CLMP

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-232

Tag: His Tag

Mouse Recombinant ASAM protein, His Tag (V2LY-0526-LY7827)

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Target: CLMP

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-232

Tag: His Tag

Human Recombinant ASAM protein, His Tag (V2LY-0526-LY2179)

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Target: CLMP

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-233

Tag: His Tag

Rabbit Anti-CLMP Recombinant Antibody (3E1) (V2LY-1206-LY255)

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Target: CLMP

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 3E1

Application*: E

Mouse Anti-CLMP Recombinant Antibody (CBFYC-1949) (V2LY-1206-LY254)

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Target: CLMP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1949

Application*: E, F

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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