Rabbit Anti-CLMP Recombinant Antibody (C4235) (CBMAB-C4235-LY)

Name: Rabbit Anti-CLMP Recombinant Antibody (C4235)
SKU: CBMAB-C4235-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

C4235

Application

ELISA

Immunogen

Recombinant Mouse ASAM / ACAM protein.

Host Species

Rabbit

Specificity

Mouse

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CXADR Like Membrane Protein

Introduction

This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]

Entrez Gene ID

79827

UniProt ID

Q9H6B4

Alternative Names

CXADR Like Membrane Protein; Coxsackie- And Adenovirus Receptor-Like Membrane Protein; Adipocyte-Specific Adhesion Molecule; Adipocyte Adhesion Molecule; CAR-Like Membrane Protein; ACAM;

Function

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development.

Biological Process

Digestive tract development Source: UniProtKB

Cellular Location

Cell membrane; Tight junction

Involvement in disease

Congenital short bowel syndrome (CSBS):
A disease characterized by a shortened small intestine, intestinal malrotation, and malabsorption. The mean length of the small intestine in CSBS patients is approximately 50 cm, compared with a normal length at birth of 190-280 cm. Patients with CSBS may develop severe malnutrition as a result of the hugely reduced absorptive surface of the small intestine. Infants require parenteral nutrition for survival. However, parenteral nutrition itself causes life-threatening complications such as sepsis and liver failure which are associated with a high rate of mortality early in life.

Topology

Extracellular: 19-235
Helical: 236-256
Cytoplasmic: 257-373

Mamoor, S. (2021). Differential expression of CXADR-like membrane protein in cancers of the breast.

Han, X., Zhao, Z. A., Yan, S., Lei, W., Wu, H., Lu, X. A., ... & Hu, S. (2020). CXADR‐like membrane protein protects against heart injury by preventing excessive pyroptosis after myocardial infarction. Journal of cellular and molecular medicine, 24(23), 13775-13788.

Chuang, Y. H., Fan, W. L., Chu, Y. D., Liang, K. H., Yeh, Y. M., Chen, C. C., ... & Lai, M. W. (2020). Whole-Exome Sequencing Identified Novel CLMP Mutations in a Family With Congenital Short Bowel Syndrome Presenting Differently in Two Probands. Frontiers in Genetics, 11, 1610.

Gharesouran, J., Esfahani, B. S., Valilou, S. F., Moradi, M., Mousavi, M. H., & Rezazadeh, M. (2019). First report of congenital short bowel syndrome in an Iranian patient caused by a mutation in the CLMP gene. Journal of pediatric genetics, 8(02), 073-080.

Langhorst, H., Jüttner, R., Groneberg, D., Mohtashamdolatshahi, A., Pelz, L., Purfürst, B., ... & Rathjen, F. G. (2018). The IgCAM CLMP regulates expression of Connexin43 and Connexin45 in intestinal and ureteral smooth muscle contraction in mice. Disease models & mechanisms, 11(2), dmm032128.

Nusrat, A., Parkos, C. A., & Luissint, A. C. (2018). CLMP-mediated regulation of intestinal homeostasis in IBD. University of Michigan Ann Arbor United States.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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