CMPK1
This gene encodes one of the enzymes required for cellular nucleic acid biosynthesis. This enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants.
Full Name
cytidine/uridine monophosphate kinase 1
Function
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
Biological Process
de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
CDP biosynthetic process Source: GO_Central
Nucleobase-containing small molecule interconversion Source: Reactome
Nucleoside diphosphate phosphorylation Source: UniProtKB
Nucleoside triphosphate biosynthetic process Source: UniProtKB
Pyrimidine ribonucleotide biosynthetic process Source: ProtInc
UDP biosynthetic process Source: GO_Central
CDP biosynthetic process Source: GO_Central
Nucleobase-containing small molecule interconversion Source: Reactome
Nucleoside diphosphate phosphorylation Source: UniProtKB
Nucleoside triphosphate biosynthetic process Source: UniProtKB
Pyrimidine ribonucleotide biosynthetic process Source: ProtInc
UDP biosynthetic process Source: GO_Central
Cellular Location
Nucleus; Cytoplasm. Predominantly cytoplasmic, less than 15% nuclear.
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Anti-CMPK1 antibodies
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Target: CMPK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 1H8
Application*: WB, IH, IF
Target: CMPK1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 1A1
Application*: WB, IH, IF
Target: CMPK1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-196
Tag: His Tag
Target: CMPK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Dog
Clone: CBFYC-1974
Application*: WB
Target: CMPK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Pig, Dog
Clone: CBFYC-1973
Application*: WB, IP, IF, E
Target: CMPK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Pig, Dog
Clone: CBFYC-1972
Application*: WB, IP, IF, E
Target: CMPK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 08
Application*: WB
Target: CMPK1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 07
Application*: E, IF
Target: CMPK1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D7
Application*: IF, P, WB, E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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