COL15A1

COL15A1 (Collagen Type XV Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL15A1 include Basal Laminar Drusen and Brittle Cornea Syndrome 2. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include structural molecule activity and extracellular matrix structural constituent. An important paralog of this gene is COL18A1.

Collagen Type XV Alpha 1 Chain

Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle.

Restin potently inhibits angiogenesis.

Angiogenesis Source: GO_Central
Cell adhesion Source: UniProtKB-KW
Collagen catabolic process Source: Reactome
Collagen fibril organization Source: Reactome
Endothelial cell morphogenesis Source: GO_Central
Extracellular matrix organization Source: GO_Central
Signal transduction Source: UniProtKB

Extracellular matrix

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate.