CREG1

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq]

cellular repressor of E1A-stimulated genes 1

May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.

Multicellular organism development Source: ProtInc
Neutrophil degranulation Source: Reactome
Regulation of growth Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: ProtInc

Secreted

N-glycosylated.