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Mouse Anti-CREG1 Recombinant Antibody (CBFYC-2203) (V2LY-1206-LY1131)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-2203
Antibody Isotype
IgG2b
Application
IHC-P, WB

Basic Information

Immunogen
Recombinant human CREG Arg32-Gln220.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cellular repressor of E1A-stimulated genes 1
Entrez Gene ID
8804
UniProt ID
O75629
Function
May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
Biological Process
Multicellular organism development Source: ProtInc
Neutrophil degranulation Source: Reactome
Regulation of growth Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: ProtInc
Cellular Location
Secreted
PTM
N-glycosylated.
More Infomation

Wu, M., Yin, F., Wei, X., Ren, R., Chen, C., Liu, M., ... & Wang, H. (2022). Hepatocyte-specific deletion of cellular repressor of E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by activating stress kinases. International Journal of Biological Sciences, 18(4), 1612-1626.

Kusudo, T., Okada, T., Hashimoto, M., Takeuchi, T., Endo, Y., Niwa, A., & Yamashita, H. (2022). CREG1 administration stimulates BAT thermogenesis and improves diet-induced obesity in mice. Journal of Biochemistry, 171(1), 63-73.

Endo, Y., Hashimoto, M., Kusudo, T., Okada, T., Takeuchi, T., Goto, A., & Yamashita, H. (2022). CREG1 improves diet‐induced obesity via uncoupling protein 1‐dependent manner in mice. Genes to Cells.

Song, H., Tian, X., Liu, D., Liu, M., Liu, Y., Liu, J., ... & Han, Y. (2021). CREG1 improves the capacity of the skeletal muscle response to exercise endurance via modulation of mitophagy. Autophagy, 1-17.

Hashimoto, M., Goto, A., Endo, Y., Sugimoto, M., Ueda, J., & Yamashita, H. (2021). Effects of CREG1 on age-associated metabolic phenotypes and renal senescence in mice. International Journal of Molecular Sciences, 22(3), 1276.

Liu, J., Qi, Y., Chao, J., Sathuvalli, P., Y. Lee, L., & Li, S. (2021). CREG1 promotes lysosomal biogenesis and function. Autophagy, 17(12), 4249-4265.

Gomez-Auli, A., Hillebrand, L. E., Christen, D., Günther, S. C., Biniossek, M. L., Peters, C., ... & Reinheckel, T. (2021). The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases. Cellular and Molecular Life Sciences, 78(2), 733-755.

Liu, M. L., Song, H. X., Tian, X. X., Liu, Y. X., Liu, D., Hou, Z. W., ... & Han, Y. L. (2020). Recombinant cellular repressor of e1a-stimulated genes protects against renal fibrosis in dahl salt-sensitive rats. American Journal of Nephrology, 51(5), 401-410.

Kusudo, T., Hashimoto, M., Kataoka, N., Li, Y., Nozaki, A., & Yamashita, H. (2019). CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro. The Journal of Biochemistry, 165(1), 47-55.

Tian, X., Yan, C., Liu, M., Zhang, Q., Liu, D., Liu, Y., ... & Han, Y. (2017). CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance. PLoS One, 12(5), e0176873.

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For research use only. Not intended for any clinical use.

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