Human Recombinant CREG1 protein, His Tag (V2LY-0526-LY3371)

Name: Human Recombinant CREG1 protein, His Tag
SKU: V2LY-0526-LY3371
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CREG1 protein, His Tag consist of Amino Acid: 1-220 and predicts a molecular mass of 22.5 kDa.

Molecule Mass

22.5 kDa

Sequence

Amino Acid: 1-220

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

cellular repressor of E1A-stimulated genes 1

Function

May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.

Biological Process

Multicellular organism development Source: ProtInc
Neutrophil degranulation Source: Reactome
Regulation of growth Source: UniProtKB-KW
Regulation of transcription by RNA polymerase II Source: ProtInc

Cellular Location

Secreted

PTM

N-glycosylated.

Wu, M., Yin, F., Wei, X., Ren, R., Chen, C., Liu, M., ... & Wang, H. (2022). Hepatocyte-specific deletion of cellular repressor of E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by activating stress kinases. International Journal of Biological Sciences, 18(4), 1612-1626.

Kusudo, T., Okada, T., Hashimoto, M., Takeuchi, T., Endo, Y., Niwa, A., & Yamashita, H. (2022). CREG1 administration stimulates BAT thermogenesis and improves diet-induced obesity in mice. Journal of Biochemistry, 171(1), 63-73.

Endo, Y., Hashimoto, M., Kusudo, T., Okada, T., Takeuchi, T., Goto, A., & Yamashita, H. (2022). CREG1 improves diet‐induced obesity via uncoupling protein 1‐dependent manner in mice. Genes to Cells.

Song, H., Tian, X., Liu, D., Liu, M., Liu, Y., Liu, J., ... & Han, Y. (2021). CREG1 improves the capacity of the skeletal muscle response to exercise endurance via modulation of mitophagy. Autophagy, 1-17.

Hashimoto, M., Goto, A., Endo, Y., Sugimoto, M., Ueda, J., & Yamashita, H. (2021). Effects of CREG1 on age-associated metabolic phenotypes and renal senescence in mice. International Journal of Molecular Sciences, 22(3), 1276.

Liu, J., Qi, Y., Chao, J., Sathuvalli, P., Y. Lee, L., & Li, S. (2021). CREG1 promotes lysosomal biogenesis and function. Autophagy, 17(12), 4249-4265.

Gomez-Auli, A., Hillebrand, L. E., Christen, D., Günther, S. C., Biniossek, M. L., Peters, C., ... & Reinheckel, T. (2021). The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases. Cellular and Molecular Life Sciences, 78(2), 733-755.

Liu, M. L., Song, H. X., Tian, X. X., Liu, Y. X., Liu, D., Hou, Z. W., ... & Han, Y. L. (2020). Recombinant cellular repressor of e1a-stimulated genes protects against renal fibrosis in dahl salt-sensitive rats. American Journal of Nephrology, 51(5), 401-410.

Kusudo, T., Hashimoto, M., Kataoka, N., Li, Y., Nozaki, A., & Yamashita, H. (2019). CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro. The Journal of Biochemistry, 165(1), 47-55.

Tian, X., Yan, C., Liu, M., Zhang, Q., Liu, D., Liu, Y., ... & Han, Y. (2017). CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance. PLoS One, 12(5), e0176873.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant CREG1 protein, hFc Tag (CAT#: V2LY-0526-LY8156)

Mouse Recombinant CREG1 protein, His Tag (CAT#: V2LY-0526-LY8157)

Mouse Creg1 ELISA Kit (CAT#: V2LY-0626-LY2910)

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Mouse Recombinant CREG1 protein, hFc Tag (CAT#: V2LY-0526-LY8156)

Mouse Anti-CREG1 Recombinant Antibody (CBFYC-0382) (CAT#: V2LY-1206-LY1129)

Mouse Recombinant CREG1 protein, His Tag (CAT#: V2LY-0526-LY8157)

Mouse Creg1 ELISA Kit (CAT#: V2LY-0626-LY2910)

Mouse Anti-CREG1 Recombinant Antibody (CBFYC-2203) (CAT#: V2LY-1206-LY1131)

Mouse Anti-CREG1 Recombinant Antibody (1B7) (CAT#: V2LY-1206-LY1128)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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