CRH
CRH (Corticotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with CRH include Post-Traumatic Stress Disorder and Postpartum Depression. Among its related pathways are Peptide ligand-binding receptors and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include receptor binding and neuropeptide hormone activity.
Full Name
Corticotropin Releasing Hormone
Function
Hormone regulating the release of corticotropin from pituitary gland (By similarity).
Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
Biological Process
Associative learning Source: Ensembl
Cellular response to cocaine Source: Ensembl
Cellular response to dexamethasone stimulus Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Diterpenoid metabolic process Source: Ensembl
Female pregnancy Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Hormone-mediated apoptotic signaling pathway Source: Ensembl
Hypothalamus development Source: Ensembl
Inflammatory response Source: UniProtKB
Ion homeostasis Source: Ensembl
Learning or memory Source: ProtInc
Long-term synaptic potentiation Source: Ensembl
Negative regulation of cell death Source: Ensembl
Negative regulation of circadian sleep/wake cycle, REM sleep Source: BHF-UCL
Negative regulation of epinephrine secretion Source: GO_Central
Negative regulation of gene expression Source: Ensembl
Negative regulation of glucagon secretion Source: GO_Central
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of luteinizing hormone secretion Source: Ensembl
Negative regulation of norepinephrine secretion Source: Ensembl
Negative regulation of systemic arterial blood pressure Source: Ensembl
Parturition Source: ProtInc
Positive regulation of behavioral fear response Source: Ensembl
Positive regulation of calcium ion import Source: Ensembl
Positive regulation of cAMP-mediated signaling Source: Ensembl
Positive regulation of cell death Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of circadian sleep/wake cycle, wakefulness Source: BHF-UCL
Positive regulation of corticosterone secretion Source: Ensembl
Positive regulation of corticotropin secretion Source: UniProtKB
Positive regulation of cortisol secretion Source: BHF-UCL
Positive regulation of digestive system process Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Positive regulation of protein phosphorylation Source: Ensembl
Regulation of NMDA receptor activity Source: UniProtKB
Regulation of serotonin secretion Source: Ensembl
Response to corticosterone Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to ethanol Source: Ensembl
Response to ether Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to pain Source: Ensembl
Signal transduction Source: ProtInc
Steroid metabolic process Source: Ensembl
Synaptic transmission, dopaminergic Source: UniProtKB
Cellular response to cocaine Source: Ensembl
Cellular response to dexamethasone stimulus Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Diterpenoid metabolic process Source: Ensembl
Female pregnancy Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Hormone-mediated apoptotic signaling pathway Source: Ensembl
Hypothalamus development Source: Ensembl
Inflammatory response Source: UniProtKB
Ion homeostasis Source: Ensembl
Learning or memory Source: ProtInc
Long-term synaptic potentiation Source: Ensembl
Negative regulation of cell death Source: Ensembl
Negative regulation of circadian sleep/wake cycle, REM sleep Source: BHF-UCL
Negative regulation of epinephrine secretion Source: GO_Central
Negative regulation of gene expression Source: Ensembl
Negative regulation of glucagon secretion Source: GO_Central
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of luteinizing hormone secretion Source: Ensembl
Negative regulation of norepinephrine secretion Source: Ensembl
Negative regulation of systemic arterial blood pressure Source: Ensembl
Parturition Source: ProtInc
Positive regulation of behavioral fear response Source: Ensembl
Positive regulation of calcium ion import Source: Ensembl
Positive regulation of cAMP-mediated signaling Source: Ensembl
Positive regulation of cell death Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of circadian sleep/wake cycle, wakefulness Source: BHF-UCL
Positive regulation of corticosterone secretion Source: Ensembl
Positive regulation of corticotropin secretion Source: UniProtKB
Positive regulation of cortisol secretion Source: BHF-UCL
Positive regulation of digestive system process Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Positive regulation of protein phosphorylation Source: Ensembl
Regulation of NMDA receptor activity Source: UniProtKB
Regulation of serotonin secretion Source: Ensembl
Response to corticosterone Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to ethanol Source: Ensembl
Response to ether Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to pain Source: Ensembl
Signal transduction Source: ProtInc
Steroid metabolic process Source: Ensembl
Synaptic transmission, dopaminergic Source: UniProtKB
Cellular Location
Secreted
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Anti-CRH antibodies
+ Filters

Target: CRH
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B11
Application*: E, WB
Target: CRH
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat, Pig, Dog, Pig
Clone: CBCNC-349
Application*: WB, IF, P, IP
Target: CRH
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-1691
Application*: E, WB, IP
Target: CRH
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-0562
Application*: E
Target: CRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 1437
Application*: E, P
Target: CRH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1435
Application*: E, P, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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