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Mouse Anti-CRH Recombinant Antibody (2B11) (CBMAB-C4659-LY)

This product is antibody recognizes CRH. The antibody 2B11 immunoassay techniques such as: WB, IP, ELISA.
See all CRH antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B11
Antibody Isotype
IgG
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Corticotropin Releasing Hormone
Introduction
CRH (Corticotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with CRH include Post-Traumatic Stress Disorder and Postpartum Depression. Among its related pathways are Peptide ligand-binding receptors and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include receptor binding and neuropeptide hormone activity.
Entrez Gene ID
UniProt ID
Alternative Names
Corticotropin Releasing Hormone; Corticotropin-Releasing Factor; Corticoliberin; CRF; Corticotropin-Releasing Hormone; CRH1;
Function
Hormone regulating the release of corticotropin from pituitary gland (By similarity).

Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).
Biological Process
Associative learning Source: Ensembl
Cellular response to cocaine Source: Ensembl
Cellular response to dexamethasone stimulus Source: Ensembl
Chemical synaptic transmission Source: ProtInc
Diterpenoid metabolic process Source: Ensembl
Female pregnancy Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Hormone-mediated apoptotic signaling pathway Source: Ensembl
Hypothalamus development Source: Ensembl
Inflammatory response Source: UniProtKB
Ion homeostasis Source: Ensembl
Learning or memory Source: ProtInc
Long-term synaptic potentiation Source: Ensembl
Negative regulation of cell death Source: Ensembl
Negative regulation of circadian sleep/wake cycle, REM sleep Source: BHF-UCL
Negative regulation of epinephrine secretion Source: GO_Central
Negative regulation of gene expression Source: Ensembl
Negative regulation of glucagon secretion Source: GO_Central
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of luteinizing hormone secretion Source: Ensembl
Negative regulation of norepinephrine secretion Source: Ensembl
Negative regulation of systemic arterial blood pressure Source: Ensembl
Parturition Source: ProtInc
Positive regulation of behavioral fear response Source: Ensembl
Positive regulation of calcium ion import Source: Ensembl
Positive regulation of cAMP-mediated signaling Source: Ensembl
Positive regulation of cell death Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of circadian sleep/wake cycle, wakefulness Source: BHF-UCL
Positive regulation of corticosterone secretion Source: Ensembl
Positive regulation of corticotropin secretion Source: UniProtKB
Positive regulation of cortisol secretion Source: BHF-UCL
Positive regulation of digestive system process Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Positive regulation of protein phosphorylation Source: Ensembl
Regulation of NMDA receptor activity Source: UniProtKB
Regulation of serotonin secretion Source: Ensembl
Response to corticosterone Source: Ensembl
Response to drug Source: Ensembl
Response to estrogen Source: Ensembl
Response to ethanol Source: Ensembl
Response to ether Source: Ensembl
Response to immobilization stress Source: Ensembl
Response to pain Source: Ensembl
Signal transduction Source: ProtInc
Steroid metabolic process Source: Ensembl
Synaptic transmission, dopaminergic Source: UniProtKB
Cellular Location
Secreted

Walia, R., Gupta, R., Bhansali, A., Pivonello, R., Kumar, R., Singh, H., ... & Shukla, J. (2021). Molecular imaging targeting corticotropin-releasing hormone receptor for corticotropinoma: A changing paradigm. The Journal of Clinical Endocrinology & Metabolism, 106(4), 1816-1826.

Takefuji, M., & Murohara, T. (2019). Corticotropin-releasing hormone family and their receptors in the cardiovascular system. Circulation Journal, 83(2), 261-266.

Duran, B. G., Castañeda, E., & Armijo, F. (2019). Development of an electrochemical impedimetric immunosensor for Corticotropin Releasing Hormone (CRH) using half-antibody fragments as elements of biorecognition. Biosensors and Bioelectronics, 131, 171-177.

Cramer, T., Rosenberg, T., Kisliouk, T., & Meiri, N. (2019). Early-life epigenetic changes along the corticotropin-releasing hormone (CRH) gene influence resilience or vulnerability to heat stress later in life. Molecular psychiatry, 24(7), 1013-1026.

Paretkar, T., & Dimitrov, E. (2018). The central amygdala corticotropin-releasing hormone (CRH) neurons modulation of anxiety-like behavior and hippocampus-dependent memory in mice. Neuroscience, 390, 187-197.

Inda, C., Armando, N. G., dos Santos Claro, P. A., & Silberstein, S. (2017). Endocrinology and the brain: corticotropin-releasing hormone signaling. Endocrine Connections, 6(6), R99-R120.

Kano, M., Muratsubaki, T., Van Oudenhove, L., Morishita, J., Yoshizawa, M., Kohno, K., ... & Fukudo, S. (2017). Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome. Scientific reports, 7(1), 1-11.

Ketchesin, K. D., Stinnett, G. S., & Seasholtz, A. F. (2017). Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans. Stress, 20(5), 449-464.

Curran, M. M., Sandman, C. A., Poggi Davis, E., Glynn, L. M., & Baram, T. Z. (2017). Abnormal dendritic maturation of developing cortical neurons exposed to corticotropin releasing hormone (CRH): Insights into effects of prenatal adversity?. PLoS One, 12(6), e0180311.

Zhang, R., Asai, M., Mahoney, C. E., Joachim, M., Shen, Y., Gunner, G., & Majzoub, J. A. (2017). Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice. Molecular psychiatry, 22(5), 733-744.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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