CROT

This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described

carnitine O-octanoyltransferase

Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.

Carnitine metabolic process Source: UniProtKB
Coenzyme A metabolic process Source: UniProtKB
Fatty acid beta-oxidation Source: UniProtKB
Fatty acid beta-oxidation using acyl-CoA oxidase Source: Reactome
Fatty acid metabolic process Source: UniProtKB
Fatty acid transport Source: Ensembl
Generation of precursor metabolites and energy Source: UniProtKB
Medium-chain fatty acid metabolic process Source: UniProtKB
Protein localization Source: Reactome

Peroxisome