Mouse Anti-CROT Recombinant Antibody (CBXC-0567) (V2LY-1206-LY1210)

Name: Mouse Anti-CROT Recombinant Antibody (CBXC-0567)
SKU: V2LY-1206-LY1210
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBXC-0567

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

CROT (aa2-99) partial recombinant protein.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

carnitine O-octanoyltransferase

Entrez Gene ID

Human	54677
Mouse	74114
Rat	83842

UniProt ID

Human	Q9UKG9
Mouse	Q9DC50
Rat	P11466

Function

Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.

Biological Process

Carnitine metabolic process Source: UniProtKB
Coenzyme A metabolic process Source: UniProtKB
Fatty acid beta-oxidation Source: UniProtKB
Fatty acid beta-oxidation using acyl-CoA oxidase Source: Reactome
Fatty acid metabolic process Source: UniProtKB
Fatty acid transport Source: Ensembl
Generation of precursor metabolites and energy Source: UniProtKB
Medium-chain fatty acid metabolic process Source: UniProtKB
Protein localization Source: Reactome

Cellular Location

Peroxisome

More Infomation

References

Okui, T., Iwashita, M., Rogers, M. A., Halu, A., Atkins, S. K., Kuraoka, S., ... & Aikawa, E. (2021). CROT (carnitine O-Octanoyltransferase) is a novel contributing factor in vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(2), 755-768.

Okui, T., Iwashita, M., Rogers, M. A., Kuraoka, S., Halu, A., Sawada, Y., ... & Aikawa, E. (2021). Carnitine O-octanoyltransferase Inhibition Attenuates Human Aortic Valve Interstitial Cell Calcification by Correcting Energetic Mitochondrial State. Circulation, 144(Suppl_1), A12316-A12316.

Zhao, Q., Sun, H., Yin, L., & Wang, L. (2019). miR‑126a‑5p‑Dbp and miR‑31a‑Crot/Mrpl4 interaction pairs crucial for the development of hypertension and stroke. Molecular medicine reports, 20(5), 4151-4167.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CROT Recombinant Antibody (CBXC-0566)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote
Second antibody and isotype control

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