Mouse Anti-CROT Recombinant Antibody (CBXC-0566) (V2LY-1206-LY1209)

Name: Mouse Anti-CROT Recombinant Antibody (CBXC-0566)
SKU: V2LY-1206-LY1209
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-0566

Application

WB, IP, IF, ELISA

Immunogen

Amino acids 1-300 mapping at the N-terminus of human CROT.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% gelatin

Preservative

0.09% sodium azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

carnitine O-octanoyltransferase

Entrez Gene ID

Human	54677
Mouse	74114
Rat	83842

UniProt ID

Human	Q9UKG9
Mouse	Q9DC50
Rat	P11466

Function

Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.

Biological Process

Carnitine metabolic process Source: UniProtKB
Coenzyme A metabolic process Source: UniProtKB
Fatty acid beta-oxidation Source: UniProtKB
Fatty acid beta-oxidation using acyl-CoA oxidase Source: Reactome
Fatty acid metabolic process Source: UniProtKB
Fatty acid transport Source: Ensembl
Generation of precursor metabolites and energy Source: UniProtKB
Medium-chain fatty acid metabolic process Source: UniProtKB
Protein localization Source: Reactome

Cellular Location

Peroxisome

Okui, T., Iwashita, M., Rogers, M. A., Halu, A., Atkins, S. K., Kuraoka, S., ... & Aikawa, E. (2021). CROT (carnitine O-Octanoyltransferase) is a novel contributing factor in vascular calcification via promoting fatty acid metabolism and mitochondrial dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(2), 755-768.

Okui, T., Iwashita, M., Rogers, M. A., Kuraoka, S., Halu, A., Sawada, Y., ... & Aikawa, E. (2021). Carnitine O-octanoyltransferase Inhibition Attenuates Human Aortic Valve Interstitial Cell Calcification by Correcting Energetic Mitochondrial State. Circulation, 144(Suppl_1), A12316-A12316.

Zhao, Q., Sun, H., Yin, L., & Wang, L. (2019). miR‑126a‑5p‑Dbp and miR‑31a‑Crot/Mrpl4 interaction pairs crucial for the development of hypertension and stroke. Molecular medicine reports, 20(5), 4151-4167.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Human Recombinant CROT (474 Leu/Val) protein, His Tag (CAT#: V2LY-0526-LY3384)

Mouse Anti-CROT Recombinant Antibody (CBXC-0567) (CAT#: V2LY-1206-LY1210)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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