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CSE1L

CSE1L (Chromosome Segregation 1 Like) is a Protein Coding gene. Diseases associated with CSE1L include Colorectal Cancer. Among its related pathways are Direct p53 effectors and p53 pathway. Gene Ontology (GO) annotations related to this gene include binding.

Full Name

Chromosome Segregation 1 Like

Function

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Biological Process

Protein export from nucleus Source: GO_Central
Protein import into nucleus Source: GO_Central

Cellular Location

Cytoplasm; Nucleus. Shuttles between the nucleus and the cytoplasm.

Anti-CSE1L antibodies

Mouse Anti-CSE1L Recombinant Antibody (2218C5a) (CBMAB-C0667-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2218C5a

Application*: DB, C, WB

Mouse Anti-CSE1L Recombinant Antibody (10B2614) (CBMAB-C2215-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10B2614

Application*: E, C, WB

Mouse Anti-CSE1L Recombinant Antibody (1C1) (CBMAB-C3700-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C1

Application*: E, IF, WB

Mouse Anti-CSE1L Recombinant Antibody (1C4) (CBMAB-C3734-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1C4

Application*: E, WB

Mouse Anti-CSE1L Recombinant Antibody (1E4) (CBMAB-C3952-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1E4

Application*: IF, WB

Mouse Anti-CSE1L Recombinant Antibody (2C10) (CBMAB-C4748-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2C10

Application*: E, IF, WB

Mouse Anti-CSE1L Recombinant Antibody (30F12) (CBMAB-C5470-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 30F12

Application*: WB, P, C

Mouse Anti-CSE1L Recombinant Antibody (3D8) (CBMAB-C5903-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 3D8

Application*: E, IF, WB

Mouse Anti-CSE1L Recombinant Antibody (729) (CBMAB-C8436-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: 729

Application*: WB

Mouse Anti-CSE1L Recombinant Antibody (8J103) (CBMAB-C9239-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 8J103

Application*: DB, WB

Mouse Anti-CSE1L Recombinant Antibody (3F8) (CBMAB-X0007-YC)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3F8

Application*: E, ICC, IF, P, WB

Mouse Anti-CSE1L Recombinant Antibody (CBXC-0581) (CBMAB-C5151-CQ)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0581

Application*: E, IC, WB

Mouse Anti-CSE1L Recombinant Antibody (CBXC-2579) (CBMAB-C5152-CQ)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: CBXC-2579

Application*: WB

Mouse Anti-CSE1L Recombinant Antibody (CBYY-C2898) (CBMAB-C4341-YY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBYY-C2898

Application*: WB

Mouse Anti-CSE1L Recombinant Antibody (P5111) (CBMAB-C11207-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: P5111

Application*: WB

Mouse Anti-CSE1L Recombinant Antibody (P729) (CBMAB-C11208-LY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: P729

Application*: WB

Mouse Anti-CSE1L (AA 872-971) Recombinant Antibody (CBFYC-2267) (CBMAB-C2339-FY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYC-2267

Application*: E, IF, WB

Mouse Anti-CSE1L Recombinant Antibody (CBFYC-2268) (CBMAB-C2340-FY)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-2268

Application*: DB, IC, WB

Rabbit Anti-CSE1L Recombinant Antibody (CBWJC-3163) (CBMAB-C4351WJ)

SDS

Target: CSE1L

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBWJC-3163

Application*: WB

Mouse Anti-CSE1L Recombinant Antibody (GT5111) (CBMAB-C4352WJ)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Rat

Clone: GT5111

Application*: WB

Mouse Anti-CSE1L Recombinant Antibody (CBWJC-3164) (CBMAB-C4353WJ)

SDS

Target: CSE1L

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat

Clone: CBWJC-3164

Application*: WB

CSE1L Matched Antibody Pair (303) (APMAB-303LY)

SDS

Target: CSE1L

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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