CSE1L

CSE1L (Chromosome Segregation 1 Like) is a Protein Coding gene. Diseases associated with CSE1L include Colorectal Cancer. Among its related pathways are Direct p53 effectors and p53 pathway. Gene Ontology (GO) annotations related to this gene include binding.

Chromosome Segregation 1 Like

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Protein export from nucleus Source: GO_Central
Protein import into nucleus Source: GO_Central

Cytoplasm; Nucleus. Shuttles between the nucleus and the cytoplasm.