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Mouse Anti-CSE1L Recombinant Antibody (729) (CBMAB-C8436-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
729
Antibody Isotype
IgG2a
Application
WB, IF

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the center region of human CSE1L.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:3,000
IF(ICC)1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chromosome Segregation 1 Like
Introduction
CSE1L (Chromosome Segregation 1 Like) is a Protein Coding gene. Diseases associated with CSE1L include Colorectal Cancer. Among its related pathways are Direct p53 effectors and p53 pathway. Gene Ontology (GO) annotations related to this gene include binding.
Entrez Gene ID
Human1434
Mouse110750
Rat362273
UniProt ID
HumanP55060
MouseQ9ERK4
RatD3ZPR0
Alternative Names
Chromosome Segregation 1 Like; Cellular Apoptosis Susceptibility Protein; Chromosome Segregation 1-Like Protein; Importin-Alpha Re-Exporter; Exp2; XPO2; CAS; Chromosome Segregation 1 (Yeast Homolog)-Like;
Function
Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Biological Process
Protein export from nucleus Source: GO_Central
Protein import into nucleus Source: GO_Central
Cellular Location
Cytoplasm; Nucleus. Shuttles between the nucleus and the cytoplasm.
More Infomation

Tunccan, T., Duzer, S., Dilek, G., Yuksel, U. M., Cetiner, H., Kılıc, C., ... & Duran, A. B. (2021). The role of CSE1L expression in cervical lymph node metastasis of larynx tumors. Brazilian Journal of Otorhinolaryngology, 87, 42-46.

Zhang, X., Zhang, X., Mao, T., Xu, H., Cui, J., Lin, H., & Wang, L. (2021). CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway. Journal of Cancer, 12(10), 2797.

Luo, Y., Qu, X., Kan, D., & Cai, B. (2021). The microRNA-451a/chromosome segregation 1-like axis suppresses cell proliferation, migration, and invasion and induces apoptosis in nasopharyngeal carcinoma. Bioengineered, 12(1), 6967-6980.

Zhou, Y., Zhou, Q., Li, L., Gu, Y., Sun, X., Wang, S., & Wang, X. (2021). Functional regulation of human trophoblast cells by CSE1L. The Journal of Maternal-Fetal & Neonatal Medicine, 34(10), 1598-1605.

Zhou, S., Zhang, M., Zhou, C., Meng, Y., Yang, H., & Ye, W. (2021). FLVCR1 Predicts Poor Prognosis and Promotes Malignant Phenotype in Esophageal Squamous Cell Carcinoma via Upregulating CSE1L. Frontiers in oncology, 11, 975.

Lin, H. C., Li, J., Cheng, D. D., Zhang, X., Yu, T., Zhao, F. Y., ... & Yao, M. (2021). Nuclear export protein CSE1L interacts with P65 and promotes NSCLC growth via NF-κB/MAPK pathway. Molecular Therapy-Oncolytics, 21, 23-36.

Nagashima, S., Maruyama, J., Honda, K., Kondoh, Y., Osada, H., Nawa, M., ... & Hata, Y. (2021). CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. Journal of Biological Chemistry, 297(1).

Wang, Y. S., Peng, C., Guo, Y., & Li, Y. (2020). CSE1L promotes proliferation and migration in oral cancer through positively regulating MITF. Eur Rev Med Pharmacol Sci, 24(10), 5429-5435.

Dong, Q., Li, X., Wang, C. Z., Xu, S., Yuan, G., Shao, W., ... & Zhu, B. (2018). Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing. Proceedings of the National Academy of Sciences, 115(17), E4013-E4022.

Cheng, D. D., Lin, H. C., Li, S. J., Yao, M., Yang, Q. C., & Fan, C. Y. (2017). CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival. Scientific reports, 7(1), 1-13.

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For research use only. Not intended for any clinical use.

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