Mouse Anti-CSE1L Recombinant Antibody (CBXC-0581) (V2LY-1206-LY1374)

Name: Mouse Anti-CSE1L Recombinant Antibody (CBXC-0581)
SKU: V2LY-1206-LY1374
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXC-0581

Application

ELISA, IF, WB, IHC-P

Immunogen

CSE1L (aa872-971) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IF(ICC)	10 μg/ml
IHC-P	3 μg/ml
IF(ICC)	10 μg/ml
IHC-P	3 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Chromosome Segregation 1 Like

Entrez Gene ID

1434

UniProt ID

P55060

Function

Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Biological Process

Protein export from nucleus Source: GO_Central
Protein import into nucleus Source: GO_Central

Cellular Location

Cytoplasm; Nucleus. Shuttles between the nucleus and the cytoplasm.

Tunccan, T., Duzer, S., Dilek, G., Yuksel, U. M., Cetiner, H., Kılıc, C., ... & Duran, A. B. (2021). The role of CSE1L expression in cervical lymph node metastasis of larynx tumors. Brazilian Journal of Otorhinolaryngology, 87, 42-46.

Zhang, X., Zhang, X., Mao, T., Xu, H., Cui, J., Lin, H., & Wang, L. (2021). CSE1L, as a novel prognostic marker, promotes pancreatic cancer proliferation by regulating the AKT/mTOR signaling pathway. Journal of Cancer, 12(10), 2797.

Luo, Y., Qu, X., Kan, D., & Cai, B. (2021). The microRNA-451a/chromosome segregation 1-like axis suppresses cell proliferation, migration, and invasion and induces apoptosis in nasopharyngeal carcinoma. Bioengineered, 12(1), 6967-6980.

Zhou, Y., Zhou, Q., Li, L., Gu, Y., Sun, X., Wang, S., & Wang, X. (2021). Functional regulation of human trophoblast cells by CSE1L. The Journal of Maternal-Fetal & Neonatal Medicine, 34(10), 1598-1605.

Zhou, S., Zhang, M., Zhou, C., Meng, Y., Yang, H., & Ye, W. (2021). FLVCR1 Predicts Poor Prognosis and Promotes Malignant Phenotype in Esophageal Squamous Cell Carcinoma via Upregulating CSE1L. Frontiers in oncology, 11, 975.

Lin, H. C., Li, J., Cheng, D. D., Zhang, X., Yu, T., Zhao, F. Y., ... & Yao, M. (2021). Nuclear export protein CSE1L interacts with P65 and promotes NSCLC growth via NF-κB/MAPK pathway. Molecular Therapy-Oncolytics, 21, 23-36.

Nagashima, S., Maruyama, J., Honda, K., Kondoh, Y., Osada, H., Nawa, M., ... & Hata, Y. (2021). CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. Journal of Biological Chemistry, 297(1).

Wang, Y. S., Peng, C., Guo, Y., & Li, Y. (2020). CSE1L promotes proliferation and migration in oral cancer through positively regulating MITF. Eur Rev Med Pharmacol Sci, 24(10), 5429-5435.

Dong, Q., Li, X., Wang, C. Z., Xu, S., Yuan, G., Shao, W., ... & Zhu, B. (2018). Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing. Proceedings of the National Academy of Sciences, 115(17), E4013-E4022.

Cheng, D. D., Lin, H. C., Li, S. J., Yao, M., Yang, Q. C., & Fan, C. Y. (2017). CSE1L interaction with MSH6 promotes osteosarcoma progression and predicts poor patient survival. Scientific reports, 7(1), 1-13.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

CSE1L Matched Antibody Pair (303) (CAT#: APMAB-303LY)

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Isotype control

For research use only. Not intended for any clinical use.

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