DEFB4B

Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. DEFB4B is an antibiotic peptide which is locally regulated by inflammation.
Full Name
Defensin Beta 4B
Function
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Cell chemotaxis Source: GO_Central
Chemotaxis Source: UniProtKB
Defense response to bacterium Source: MGI
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
G protein-coupled receptor signaling pathway Source: ProtInc
Immune response Source: ProtInc
Killing of cells of other organism Source: UniProtKB
Cellular Location
Secreted
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Anti-DEFB4B antibodies

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Mouse Anti-DEFB4B Recombinant Antibody (L12-4C-C2) (CBMAB-D0691-YC)

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Target: DEFB4B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: L12-4C-C2
Application*: E, WB, P
Datasheet SDS

Mouse Anti-DEFB4B Recombinant Antibody (D0691) (V2LY-0425-LY163)

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Target: DEFB4B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D0691
Application*: E
Datasheet SDS

Mouse Anti-DEFB4B Recombinant Antibody (14D56) (V2LY-0425-LY162)

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Target: DEFB4B
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 14D56
Application*: E, WB, IP
Datasheet SDS

Mouse Anti-DEFB4B Recombinant Antibody (14D56) (CBMAB-D0690-YC)

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Target: DEFB4B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14D56
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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