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Mouse Anti-DEFB4B Recombinant Antibody (L12-4C-C2) (CBMAB-D0691-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Defensin Beta 4B (DEFB4B). The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC-P.
See all DEFB4B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
L12-4C-C2
Antibody Isotype
IgG1
Application
ELISA, WB, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 4-41

Target

Full Name
Defensin Beta 4B
Introduction
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. DEFB4B is an antibiotic peptide which is locally regulated by inflammation.
Entrez Gene ID
100289462
UniProt ID
O15263
Alternative Names
Defensin Beta 4B; Defensin, Beta 4, Pseudogene; Beta Defensin 2; Beta-Defensin 2; Skin-Antimicrobial Peptide 1; Defensin, Beta 4B; Defensin, Beta 2; Beta-Defensin 4B; Beta Defensin-2;
Function
Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells (PubMed:20068036).
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Antimicrobial humoral response Source: Reactome
Cell chemotaxis Source: GO_Central
Chemotaxis Source: UniProtKB
Defense response to bacterium Source: MGI
Defense response to Gram-negative bacterium Source: UniProtKB
Defense response to Gram-positive bacterium Source: UniProtKB
G protein-coupled receptor signaling pathway Source: ProtInc
Immune response Source: ProtInc
Killing of cells of other organism Source: UniProtKB
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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