DOCK2

The DOCK2 gene encodes a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis.[supplied by OMIM

Full Name

dedicator of cytokinesis 2

Function

Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.

Biological Process

Actin cytoskeleton organization Source: UniProtKB
Alpha-beta T cell proliferation Source: Ensembl
Chemotaxis Source: Ensembl
Establishment of T cell polarity Source: Ensembl
Immunological synapse formation Source: Ensembl
Macropinocytosis Source: UniProtKB
Membrane raft polarization Source: Ensembl
Myeloid dendritic cell activation involved in immune response Source: UniProtKB
Negative thymic T cell selection Source: Ensembl
Positive regulation of phagocytosis Source: UniProtKB
Positive thymic T cell selection Source: Ensembl
Regulation of small GTPase mediated signal transduction Source: Reactome
Small GTPase mediated signal transduction Source: InterPro

Cellular Location

Cytoskeleton; Endomembrane system. Colocalizes with F-actin.

Involvement in disease

Immunodeficiency 40 (IMD40):
A form of combined immunodeficiency characterized by lymphopenia, and defective T-cell, B-cell, and NK-cell responses. Patients suffer from severe invasive bacterial and viral infections in early childhood and may die without bone marrow transplantation.