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E2F3

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq]

Full Name

E2F transcription factor 3

Research Area

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).

Biological Process

G1/S transition of mitotic cell cycle Source: UniProtKB
Negative regulation of fat cell proliferation Source: UniProtKB
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of vascular associated smooth muscle cell apoptotic process Source: BHF-UCL
Protein import into nucleus Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription initiation from RNA polymerase II promoter Source: ProtInc

Cellular Location

Nucleus

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Anti-E2F3 antibodies

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Mouse Anti-E2F3 Recombinant Antibody (5F7) (V2LY-0425-LY1237)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5F7

Application*: E, WB, PLA

Mouse Anti-E2F3 Recombinant Antibody (CBFYE-0370) (V2LY-0425-LY1236)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYE-0370

Application*: E

Mouse Anti-E2F3 Recombinant Antibody (CBFYE-0368) (V2LY-0425-LY1235)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-0368

Application*: IP, WB

Mouse Anti-E2F3 Recombinant Antibody (CBFYE-0367) (V2LY-0425-LY1234)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-0367

Application*: IP, WB

Mouse Anti-E2F3 Recombinant Antibody (CBFYE-0004) (V2LY-0425-LY1233)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-0004

Application*: IP, WB

Mouse Anti-E2F3 Recombinant Antibody (CBFYE-0003) (V2LY-0425-LY1232)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Rat

Clone: CBFYE-0003

Application*: WB, IP, IF, E

Mouse Anti-E2F3 Recombinant Antibody (5F7) (CBMAB-A2415-LY)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 5F7

Application*: SE, E

Mouse Anti-E2F3 Recombinant Antibody (CBFYE-0370) (CBMAB-E0671-FY)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYE-0370

Application*: IF, IH, WB

Mouse Anti-E2F3 (AA 1-133) Recombinant Antibody (CBFYE-0368) (CBMAB-E0669-FY)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYE-0368

Application*: E

Mouse Anti-E2F3 (AA 336-426) Recombinant Antibody (CBFYE-0367) (CBMAB-E0668-FY)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYE-0367

Application*: E, WB, PL

Mouse Anti-E2F3 Recombinant Antibody (CBFYE-0004) (CBMAB-E0011-FY)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYE-0004

Application*: IF

Mouse Anti-E2F3 Recombinant Antibody (CBFYE-0003) (CBMAB-E0010-FY)

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Target: E2F3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYE-0003

Application*: IC, IP, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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