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Mouse Anti-E2F3 Recombinant Antibody (CBFYE-0003) (CBMAB-E0010-FY)

This product is mouse antibody that recognizes E2F3. The antibody CBFYE-0003 can be used for immunoassay techniques such as: ICC, IP, WB.
See all E2F3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0003
Antibody Isotype
IgG
Application
ICC, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
E2F transcription factor 3
Introduction
This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle.
Entrez Gene ID
1871
UniProt ID
O00716
Alternative Names
E2F-3
Research Area
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity).
Biological Process
G1/S transition of mitotic cell cycle Source: UniProtKB
Negative regulation of fat cell proliferation Source: UniProtKB
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Positive regulation of vascular associated smooth muscle cell apoptotic process Source: BHF-UCL
Protein import into nucleus Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Transcription initiation from RNA polymerase II promoter Source: ProtInc
Cellular Location
Nucleus

Yan, X., Wang, T., & Wang, J. (2022). Circ_0016760 acts as a sponge of microRNA-4295 to enhance E2F transcription factor 3 expression and facilitates cell proliferation and glycolysis in non-small cell lung cancer. Cancer Biotherapy & Radiopharmaceuticals, 37(2), 147-158.

Wu, X., Kong, C., & Wu, Y. (2021). Long intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis. Bioengineered, 12(1), 9046-9057.

Li, H., Pan, R., Lu, Q., Ren, C., Sun, J., Wu, H., ... & Chen, H. (2020). MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3. International journal of molecular medicine, 45(5), 1317-1326.

Zhao, W., Wang, S., Qin, T., & Wang, W. (2020). Circular RNA (circ‐0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3. Journal of Cellular Biochemistry, 121(7), 3516-3525.

Shi, L., Zhu, H., Shen, Y., Dou, X., Guo, H., Wang, P., ... & Zou, X. (2020). Regulation of E2F transcription factor 3 by microRNA-152 modulates gastric cancer invasion and metastasis. Cancer management and research, 12, 1187.

Santerre, M., Bagashev, A., Gorecki, L., Lysek, K. Z., Wang, Y., Shrestha, J., ... & Sawaya, B. E. (2019). HIV-1 Tat protein promotes neuronal dysregulation by inhibiting E2F transcription factor 3 (E2F3). Journal of Biological Chemistry, 294(10), 3618-3633.

Li, Q., Pan, H., & Liu, Q. (2019). MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts. Bioscience Reports, 39(12).

Liu, N., Liu, Z., Zhang, W., Li, Y., Cao, J., Yang, H., & Li, X. (2018). MicroRNA‑433 reduces cell proliferation and invasion in non‑small cell lung cancer via directly targeting E2F transcription factor 3. Molecular Medicine Reports, 18(1), 1155-1164.

Gao, X., Zhao, S., Yang, X., Zang, S., & Yuan, X. (2018). Long non-coding RNA FLVCR1-AS1 contributes to the proliferation and invasion of lung cancer by sponging miR-573 to upregulate the expression of E2F transcription factor 3. Biochemical and biophysical research communications, 505(3), 931-938.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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