ECD

ECD (ecdysoneless homolog) belongs to the SGT1 family that is highly expressed in muscle and heart. ECD is a novel promoter of mammalian cell cycle progression. ECD may function to remove the repressive effects of Rb-family tumor suppressors on E2F transcription factors and also is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells.

Full Name

ECD

Research Area

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345).

May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932).

Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839).

The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270).

May play a role in regulation of pre-mRNA splicing (PubMed:24722212).

Biological Process

Cell population proliferation Source: Ensembl
mRNA processing Source: UniProtKB-KW
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of G1/S transition of mitotic cell cycle Source: Ensembl
RNA splicing Source: UniProtKB-KW

Cellular Location

Nucleus; Cytoplasm. Predominantly is located in the cytoplasm.

PTM

Phosphorylated predominantly by CK2 on two serine-containing clusters; involved in cell cycle regulation activity.