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ECD

ECD (ecdysoneless homolog) belongs to the SGT1 family that is highly expressed in muscle and heart. ECD is a novel promoter of mammalian cell cycle progression. ECD may function to remove the repressive effects of Rb-family tumor suppressors on E2F transcription factors and also is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells.
Full Name
ECD
Research Area
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345).

May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932).

Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839).

The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270).

May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
Biological Process
Cell population proliferation Source: Ensembl
mRNA processing Source: UniProtKB-KW
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of G1/S transition of mitotic cell cycle Source: Ensembl
RNA splicing Source: UniProtKB-KW
Cellular Location
Nucleus; Cytoplasm. Predominantly is located in the cytoplasm.
PTM
Phosphorylated predominantly by CK2 on two serine-containing clusters; involved in cell cycle regulation activity.

Anti-ECD antibodies

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Target: ECD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1D10
Application*: E, IP
Target: ECD
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1C11
Application*: IP, WB, M
Target: ECD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0136
Application*: E, WB, IF
Target: ECD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0399
Application*: E, WB
Target: ECD
Host: Mouse
Antibody Isotype: IgG, λ
Specificity: Human
Clone: CBFYE-0398
Application*: E, IF, WB
Target: ECD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0020
Application*: E, IC, WB
Target: ECD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 1A11
Application*: WB, E
Target: ECD
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 1E5
Application*: WB, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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