ECD
ECD (ecdysoneless homolog) belongs to the SGT1 family that is highly expressed in muscle and heart. ECD is a novel promoter of mammalian cell cycle progression. ECD may function to remove the repressive effects of Rb-family tumor suppressors on E2F transcription factors and also is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells.
Full Name
ECD
Research Area
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345).
May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932).
Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839).
The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270).
May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932).
Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839).
The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270).
May play a role in regulation of pre-mRNA splicing (PubMed:24722212).
Biological Process
Cell population proliferation Source: Ensembl
mRNA processing Source: UniProtKB-KW
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of G1/S transition of mitotic cell cycle Source: Ensembl
RNA splicing Source: UniProtKB-KW
mRNA processing Source: UniProtKB-KW
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of G1/S transition of mitotic cell cycle Source: Ensembl
RNA splicing Source: UniProtKB-KW
Cellular Location
Nucleus; Cytoplasm. Predominantly is located in the cytoplasm.
PTM
Phosphorylated predominantly by CK2 on two serine-containing clusters; involved in cell cycle regulation activity.
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Anti-ECD antibodies
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CompareTarget: ECD
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human, Mouse
Clone: 1A11
Application*: WB, E, IF
Target: ECD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 1E5
Application*: WB, E
Target: ECD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0136
Application*: IP, IF, F
Target: ECD
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: CBFYE-0399
Application*: WB, IP, IF, E
Target: ECD
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 1-621
Tag: GST Tag
Target: ECD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1D10
Application*: E, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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