EFNA4
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin. Three transcript variants that encode distinct proteins have been identified. [provided by RefSeq, Jul 2008]
Full Name
Ephrin A4
Research Area
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils.
Biological Process
Axon guidance Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: GO_Central
Cell-cell signaling Source: ProtInc
Ephrin receptor signaling pathway Source: GO_Central
Cellular Location
Isoform 1: Cell membrane
Isoform 2: Secreted
Isoform 2: Secreted
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Anti-EFNA4 antibodies
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Target: EFNA4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 8K23
Application*: WB
Target: EFNA4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-0497
Application*: IF
Target: EFNA4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYE-0496
Application*: WB, IH
Target: EFNA4
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 1181
Application*: WB
Target: EFNA4
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYE-0497
Application*: WB
Target: EFNA4
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYE-0496
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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