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F11

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]

Full Name

Coagulation Factor XI

Research Area

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

Biological Process

Blood coagulation Source: BHF-UCL
Plasminogen activation Source: BHF-UCL
Positive regulation of fibrinolysis Source: BHF-UCL

Cellular Location

Secreted

Involvement in disease

Factor XI deficiency (FA11D):
A hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.

PTM

N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.
Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.

Anti-F11 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

F11 Matched Antibody Pair (392) (APMAB-392LY)

SDS

Target: F11

Specificity: Human

Mouse Anti-F11 Recombinant Antibody (3C7) (CBMAB-A2773-LY)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3C7

Application*: E, E

Mouse Anti-F11 Recombinant Antibody (2H8) (CBMAB-A2772-LY)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2H8

Application*: WB, E

Mouse Anti-F11 Recombinant Antibody (CBWJC-3637) (CBMAB-C4881WJ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBWJC-3637

Application*: E, FN, WB

Mouse Anti-F11 Recombinant Antibody (CBXC-3039) (CBMAB-C3939-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-3039

Application*: WB, N

Mouse Anti-F11 Recombinant Antibody (CBYY-C2444) (CBMAB-C3884-YY)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBYY-C2444

Application*: N, WB

Mouse Anti-F11 Recombinant Antibody (CBYY-C0011) (CBMAB-C0020-YY)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C0011

Application*: WB, IP, N

Mouse Anti-F11 Recombinant Antibody (CBYY-C0010) (CBMAB-C0019-YY)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYY-C0010

Application*: WB, IP

Rabbit Anti-F11 Recombinant Antibody (CBFYC-2624) (CBMAB-C2698-FY)

SDS

Target: F11

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-2624

Application*: E

Mouse Anti-F11 Recombinant Antibody (2B7E12F8) (CBMAB-C4725-LY)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2B7E12F8

Application*: E

Mouse Anti-F11 Recombinant Antibody (318101) (CBMAB-C0954-LY)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 318101

Application*: WB, IP

Mouse Anti-F11 Recombinant Antibody (CBXF-2757) (CBMAB-F3474-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-2757

Application*: E, R, WB

Mouse Anti-F11 Recombinant Antibody (CBXF-2756) (CBMAB-F3473-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-2756

Application*: E, IP, WB

Mouse Anti-F11 (AA 286-385) Recombinant Antibody (CBXF-2755) (CBMAB-F3472-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-2755

Application*: E

Mouse Anti-F11 Recombinant Antibody (CBXF-1912) (CBMAB-F2729-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: CBXF-1912

Application*: WB, N

Mouse Anti-F11 Recombinant Antibody (hfXI-2) (CBMAB-F2640-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: hfXI-2

Application*: WB, E, R, P, I

Mouse Anti-F11 Recombinant Antibody (CBXF-0137) (CBMAB-F1815-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0137

Application*: E, WB

Mouse Anti-F11 Recombinant Antibody (CBXF-3882) (CBMAB-F1654-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-3882

Application*: E, R, WB

Rabbit Anti-F11 Recombinant Antibody (CBXF-2008) (CBMAB-F1637-CQ)

SDS

Target: F11

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-2008

Application*: E

Mouse Anti-F11 Recombinant Antibody (CBXF-0139) (CBMAB-F1417-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG

Specificity: Rat

Clone: CBXF-0139

Application*: WB, IC, P, C, E

Mouse Anti-F11 Recombinant Antibody (CBXF-0138) (CBMAB-F1416-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-0138

Application*: WB, IC, P, C, E

Mouse Anti-F11 Recombinant Antibody (CBXF-2376) (CBMAB-F0717-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-2376

Application*: E, WB

Mouse Anti-F11 Recombinant Antibody (CBXF-0135) (CBMAB-F0254-CQ)

SDS

Target: F11

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-0135

Application*: E, R, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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