F11

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq, Jul 2008]
Full Name
Coagulation Factor XI
Research Area
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Biological Process
Blood coagulation Source: BHF-UCL
Plasminogen activation Source: BHF-UCL
Positive regulation of fibrinolysis Source: BHF-UCL
Cellular Location
Secreted
Involvement in disease
Factor XI deficiency (FA11D):
A hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
PTM
N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.
Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.
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Anti-F11 antibodies

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F11 Matched Antibody Pair (392) (APMAB-392LY)

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Target: F11
Specificity: Human
Datasheet SDS

Human Anti-F11 Recombinant Antibody (CBXF-1912) (CBMAB-F2729-CQ)

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Target: F11
Host: , Human,
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: CBXF-1912
Application*: E, WB, in vivo
Datasheet SDS

Mouse Anti-F11 Recombinant Antibody (CBYY-C0011) (V2LY-0825-LY1042)

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Target: F11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0011
Application*: E
Datasheet SDS

Rabbit Anti-F11 Recombinant Antibody (CBFYC-2624) (V2LY-0825-LY1040)

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Target: F11
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-2624
Application*: E
Datasheet SDS

Mouse Anti-F11 Recombinant Antibody (C4725) (V2LY-0825-LY1039)

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Target: F11
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: C4725
Application*: WB, B
Datasheet SDS

Mouse Anti-F11 Recombinant Antibody (C0954) (V2LY-0825-LY1038)

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Target: F11
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: C0954
Application*: WB, IP
Datasheet SDS

Mouse Anti-F11 Recombinant Antibody (CBXF-2757) (V2LY-0825-LY1037)

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Target: F11
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2757
Application*: WB, IP, B
Datasheet SDS

Mouse Anti-F11 Recombinant Antibody (CBXF-2756) (V2LY-0825-LY1036)

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Target: F11
Host: Mouse
Antibody Isotype: IgG4, κ
Specificity: Human
Clone: CBXF-2756
Application*: E, WB
Datasheet SDS

Rabbit Anti-F11 Recombinant Antibody (CBXF-2008) (V2LY-0825-LY1032)

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Target: F11
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2008
Application*: E
Datasheet SDS

Mouse Anti-F11 Recombinant Antibody (CBYY-C0010) (CBMAB-C0019-YY)

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Target: F11
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0010
Application*: WB, IP, IF, P, E
Datasheet SDS

Human Anti-F11 Recombinant Antibody (CBXF-2755) (CBMAB-F3472-CQ)

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Target: F11
Host: , Human,
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2755
Application*: E
Datasheet SDS

Mouse Anti-F11 Recombinant Antibody (2) (CBMAB-F2640-CQ)

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Target: F11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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