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Mouse Anti-F11 Recombinant Antibody (hfXI-2) (CBMAB-F2640-CQ)

This product is a mouse antibody that recognizes F11. The antibody hfXI-2 can be used for immunoassay techniques such as: WB, ELISA, RIA, IHC-P, Inhib.
See all F11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
hfXI-2
Antibody Isotype
IgG
Application
WB, ELISA, RIA, IHC-P, Inhib

Basic Information

Immunogen
Human Factor XI
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
7.8 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coagulation Factor XI
Introduction
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Entrez Gene ID
2160
UniProt ID
P03951
Alternative Names
Coagulation Factor XI; Plasma Thromboplastin Antecedent; FXI; PTA; EC 3.4.21.27; EC 3.4.21;
Research Area
Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
Biological Process
Blood coagulation Source: BHF-UCL
Plasminogen activation Source: BHF-UCL
Positive regulation of fibrinolysis Source: BHF-UCL
Cellular Location
Secreted
Involvement in disease
Factor XI deficiency (FA11D):
A hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.
PTM
N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures. Glycosylation at Asn-163 uses a rare non-canonical Asn-X-Cys glycosite.
Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-387 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.

Wang, H., Jiang, S., Xie, H., Yang, L., Jin, Y., & Wang, M. (2022). Genetic analysis of compound heterozygous pathogenic variants of the F11 gene in two Chinese patients with hereditary factor XI deficiency. Blood Coagulation & Fibrinolysis, 33(1), 61-66.

Cao, Y., Wang, Y., Zhou, Z., Pan, C., Jiang, L., Zhou, Z., ... & Lusis, A. J. (2022). Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure. Science, 377(6613), 1399-1406.

Yang, T., Zhu, J., Chen, X., Wang, F., Zheng, X., & Cheng, X. (2022). Detection and gene mutation analysis of three variations in two unrelated Chinese hereditary coagulation factor XI deficiency families. Acta Haematologica, 1-8.

Yang, T., Zhu, J., Yang, Q., Liu, J., Yang, L., & Wang, M. (2021). Analysis of a pedigree affected with hereditary coagulation factor XI deficiency due to compound heterozygous variants of F11 gene. Zhonghua yi xue yi Chuan xue za zhi= Zhonghua Yixue Yichuanxue Zazhi= Chinese Journal of Medical Genetics, 38(3), 242-246.

Hayakawa, Y., Tamura, S., Suzuki, N., Odaira, K., Tokoro, M., Kawashima, F., ... & Kojima, T. (2021). Essential role of a carboxyl‐terminal α‐helix motif in the secretion of coagulation factor XI. Journal of Thrombosis and Haemostasis, 19(4), 920-930.

Leung, P. Y., Li, C. K., Cheng, C. K., Ng, M. H., & Chan, N. C. (2020). A novel F11 mutation in a Chinese paediatric patient with severe factor XI deficiency. Thrombosis Research, 190, 89-90.

Ciampa, E. J., Liu, N., Stiles, J., Carani, J. L., Li, Y., & Hess, P. E. (2020). Heterozygote carriers of mutations in the F11 gene, encoding Factor XI, have normal coagulation by thromboelastography during pregnancy. International Journal of Obstetric Anesthesia, 42, 57-60.

Liu, M., Li, X., Zhou, X., Jin, Y., Yang, L., Pan, J., ... & Wang, M. (2019). Identification of compound heterozygous mutations of F11 gene in a pedigree affected with heriditary coagulation factor XI deficiency. Zhonghua yi xue yi Chuan xue za zhi= Zhonghua Yixue Yichuanxue Zazhi= Chinese Journal of Medical Genetics, 36(4), 363-367.

Colakoglu, S., Bayhan, T., Tavil, B., Keskin, E. Y., Cakir, V., Gümrük, F., ... & Berber, E. (2018). Molecular genetic analysis of the F11 gene in 14 Turkish patients with factor XI deficiency: identification of novel and recurrent mutations and their inheritance within families. Blood Transfusion, 16(1), 105.

Mohammed, B. M., Cheng, Q., Matafonov, A., Monroe, D. M., Meijers, J. C., & Gailani, D. (2018). Factor XI promotes hemostasis in factor IX‐deficient mice. Journal of Thrombosis and Haemostasis, 16(10), 2044-2049.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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