FABP6

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq]

fatty acid binding protein 6, ileal

Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity).

In vitro binds to bile acids in the order: deoxycholic acid> cholic acid> chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated> glycine-conjugated> unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).
Isoform 2:
Essential for the survival of colon cancer cells to bile acid-induced apoptosis.

Lipid metabolic process Source: ProtInc
Lipid transport Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: ProtInc

Isoform 1: Cytoplasm; Membrane
Isoform 2: Cytoplasm. Localized close to nucleus on the apical side of both normal and neoplastic cells.